ABSTRACT
Diabetic nephropathy is the most important disease which often results in renal failure. Proteinuria is an important parameter which predicts progression of diabetic nephropathy. Gold standard method for protein measuring is collecting 24 hour urine. Instead of that, in several studies around the world, measuring level of urine protein in 24 hours of the day has been carried out. In this study, we intended to specify the relation between quantitative amount of 8 hour and 24 hour urine protein in patients with diabetic nephropathy. The study population included 50 patients with diabetic nephropathy before ESRD We obtained the following samples: 1] 8-h urine, and 2] 24-h urine. We measured serum creatinine concentration, creatinine clearance, urine volume, urinary protein and creatinine concentration. Our statistic method of analysis was Pierson's correlation method. Age mean was 53 +/- 14 years old and diabetes duration mean was 13 +/- 4.10 years. The mean of nocturnal 8hr urine protein and 24 hr one were 24.20 +/- 42, 33.35 +/- 43, 71.26 +/- 84 mg, respectively. There was a direct significant correlation between 8hr and 24hr urine protein [r=0.8, p=0.001]. A significant correlation was also detected between nocturnal 8hr urine protein and daily one with 24hr urine protein. There was a significant and direct relationship between 8hr urine protein [daily and nightly] and 24hr urine protein. This might be used for urine protein collection in patients with diabetic nephropathy to improve the compliance
ABSTRACT
In this study we evaluated the body composition before and two weeks after kidney transplantation and compared it with the healthy people by BIA. A total of 23 progressive renal failure patients who attended the transplantation were recruited for this study. The control group included 27 graft donors .Patients were checked one day before hemodialysis and a day before transplantation, by BIA. After transplantation, body composition was assessed between days 1-7 and on the 14[th] day of post transplantation. The control group included 27 graft donors. The comparison of body composition between two groups [donors and recipients] showed significant changes before hemodialysis and after transplantation, and TBW% decreased from the 7[th] day post transplantation. The Main cause of low level of TBW% was the decrease in ECW% and ECW/ICW from the beginning of 2[nd] week after transplantation. Just TBW% in normal males was different from that it normal females but in recipients there was no difference between males and females. The body composition takes a long time to reach to the normal level and two weeks after transplantation some agents are probably responsible for intense changes of body composition including drugs and mild prerenal azotemia specially on the 2[nd] week after transplantation
ABSTRACT
Relative differences in QOL between hemodialysis [HD] and peritoneal dialysis [PD] are not clearly known. The objective of this study was to compare QOL between HD and PD patients in Emam Reza and Ghaem hospital dialysis centers. We compared 40 patients [17male and23 female] on PD with 40 matched patients [20 male and 20 female] on HD. Health related 36 item short form questionnaire [SF-36] were used to assess the quality of life. For the SF-36, eight domain scores [physical functioning [PF], role limitations as a result of physical problems [RP], body pain [BP], general health perceptions [GH], social functioning [SF], role limitations as a result of emotional problems [RE], vitality [VT], mental health [MH]] were calculated. We also calculated summary Physical Component [PCS], Mental Component [MCS] and total scores of QOL. This study included 80 patients treated with HD and PD. The worst score was for RP dimension in both groups, and the best score was for RE in PD patients and BP in HD patients. SF-36 domains of GH, RP, VT and PCS were all significantly higher in the PD patients as compared to the HD patients. The only domain for which significant differences favoured HD patients was BP. [P < 0.05]. This study provided evidence that patients in PD treatment modality were experiencing better quality of life in SF-36 domains of GH, RP, VT, PCS in comparison to HD patients
Subject(s)
Humans , Male , Female , Peritoneal Dialysis , Renal Dialysis , Surveys and QuestionnairesABSTRACT
Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it is associated with side effects, some of which are dose-dependent. We evaluated association between cyclosporine trough level and its side effects. In 50 kidney transplant recipients, serum cyclosporine level, fasting blood glucose, and serum creatinine were measured 7 times during first 6 months after transplantation. The participants were also assessed for blood pressure, hand tremor, and headache at each visit. The relationship between cyclosporine trough level and hypertension, hyperglycemia, hand tremor, and headache were evaluated. There were no significant relationship between cyclosporine levels and allograft function. Except at the second week and sixth month, there were no significant differences between drug doses in various serum cyclosporine trough level groups. At the second week, the mean drug dose in patients with cyclosporine trough levels less than the target therapeutic level was 279.16 +/- 56.23 mg/d, while in the patients with cyclosporine levels higher than the therapeutic level, its dose was 302.08 +/- 66.61 mg/d [P < .05]. At the sixth month, the mean drug dose was 137.50 +/- 17.67 mg/d in the patients with lower than target cyclosporine levels, and it was 242.18 +/- 58.25 mg/d in those with cyclosporine levels higher than the therapeutic level [P < .05]. There was no significant relationship between serum cyclosporine level and its side effects. We demonstrated cyclosporine trough level had no direct relation with drug side effects and it is not a suitable measure for assessment of drug side effects