ABSTRACT
Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases [GSTs] genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent
Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population
Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods
Results: The GSTM1 null genotype was significantly higher [p=0.027] in the cases [7.3%] than the control group [1.3%]. There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower [p=0.048] in the case [33.1%] than the control group [44.4%]
Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women