ABSTRACT
Background: N-acetyl cysteine [NAC] was proposed as an adjuvant to clomiphene citratefor ovulation induction in patients with polycystic ovary syndrome [PCOS] without clomiphene citrate resistance
Objective: to evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination
Materials and Methods: in this randomized clinical trial 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group [n=49], NAC [1.2 gr]+ clomiphene citrate [100 mg] + letrozole [5mg] were prescribed Daily from the third day of menstruation cycle for five days. The control group [n=48] had the same drug regimen without NAC. In order to follicular development, GONALF was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, HCG [10000 IU] was injected intramuscular and the intrauterine insemination was performed after 34-36 hr
Results: there were not significant differences between study groups regarding mean endometrial thickness [p=0.14], mean number of mature follicles [p=0.20] and the pregnancy rate [p=0.09]
Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients