Comparison of effectiveness of lovastatin and gemfibrozil on HDL-C level in diabetic type 2 patients

Diabetes mellitus is the most common human metabolic disease. Chronic hyperglycemia and carbohydrate metabolism disorder accompany with plasma lipid and lipoprotein disorder. Cardiovascular disease is one of the macro vascular complications of diabetes type 2 which leads to high morbidity and mortality. Dyslipidemia is one of the major risk factors of cardiovascular diseases in diabetic patients. High TG and low HDL-C levels are the most prevalent type of dyslipidemia. Low levels of HDL-c considered as a risk factor for cardiovascular diseases. In this study 40 type 2 diabetic patients [13 male - 27 female] were included. Lovastatin and Gemfibrozil were recommended separately for 2 months and HDL-C were measured at the baseline and after taking drugs. In all patients BS, TG and TC at the baseline before and after these drugs were normal and so were not any change in their diet. Laboratorial findings gathered and analyzed. The relationship between increase level of HDL and decrease of TC with taking Lovastatin and Gemfibrozil were studied. The averages of TC and HDL-C before taking drug as linear were 36.5mg/dl and 174.56 mg/dl and after taking Lovastatin as linear were 43.3 mg/dl and 150.44 mg/dl. The average of TC and HDL-C after taking Gemfibrozil were 43.33mg/dl and 146.36mg/dl. 18.54% increase in HDL-C and 13.82% decrease in TC were seen with Lovastatin; and 18.54% increase in HDL-C and 16.05% decrease in TC were found with Gemfibrozil. In this study no difference was observed between the effect of Lovastatin and Gemfibrozil in increase of HDL-C [P=0.449]. Also there was no difference between the effect of Lovastatin and Gemfibrozil in decrease of TC [P=0.992]. The increase of HDL-C after taking Lovastatin had relation with sex and HDL-C increased in females [P=0.006]; Also the increase of HDL-C after taking Gemfibrozil had relation with sex and females had more affected [P=0.035]

[Epidemiological study of familial diabetes type 2 in Tehran]

Background: diabetes type 2 is one of the most prevalent reasons of Hyperglycemia. Different areas experience varying degrees of epidemic intensity. Diabetes is one of the most important causes of death and disability in most countries and imposes heavy financial burdens on people and governments. Although much research has been conducted on its prevention and treatment. It has been recognized as a hereditary disease, the genes causing it or its mode of inheritance are not yet known. Because of the significant role they play in metabolism of glucose, several genes have suggested, but the main cause of the disease has not yet been identified. Our objective is to investigate the epidemic aspects of the hereditary diabetes in people aged 20 years and over

Methods: a cross sectional study was conducted on 14687 subjects, in the urban setting of east Tehran between 1379 and 1380. Of 407 families, 180 agreed to and completed related questionnaires and underwent the necessary tests 180 diabetic families, with at least one member suffering from diabetes type 2, were studied closely in order to clarify the degree of spread and family background. Analysis was performed using Chi Square and t-test

Results: of 1612 subjects, 497 had diabetes, including 802 women and 792 men [p<0. 001]. Most of the diabetics [approx. 79%] were between the ages of 41-70 years old with the highest [55.3%] and lowest [6.2%] rates in the age groups of 51-60 and 20-30 years respectively. Diabetes was more prevalent among siblings with 53% in comparison to the prevalence among offsprings-44%. The prevalence of Diabetes type 2 in first-degree relatives was more frequent between sister and brother [52.7%], followed by that between father and daughter [36%]

Conclusion: it is recommended that the related authorities implement strategies, including screening of families, with a view to identify those at risk and reduce related complications

[Prevalence of DM - IGT and IFG in first degree relative family members of type 2 diabetes in Tabriz. [Greater than 30 years]]

Background: type 2 diabetes is a hereditary disease but the inheritance and responsible genes have not been clearly clarified yet. According to the most studies, diabetes is one of the most common causes of mortality and morbidity in populations. Diabetes occurs in 30% of first degree family members of diabetic patients, But most people are not aware of their disease

Methods: we studied first degree relatives of type 2 diabetes and screened them for diabetes, IFG and IGT.174 families[1556 people] of Tabriz residents were studied, among them 1232 persons grater than 30 years were alive and FBS and OGTT were done in this group

Results: according to this study, 1232 persons were alive and 324 persons had died and DM was found in 343 [27.9%] and 82 [25.3%] of them respectively. We found 179 [14.5%] persons with IFG and 89 [7.2%] with IGT.The percent of diabetes in offspring and siblings were 32.9% and 22.1% respectively. The majority of patients had 41 - 50 years old. Risk of diabetes among offspring who had diabetes in both parents was more than the ones who had diabetic father or mother. In this study, women with diabetes were more than men [32.4% vs. 22.2% respectively]. The prevalence of Diabetes type 2 in first-degree relatives was more frequent between sister and brother [41.95%], followed by that between father and son [10.9%]

Conclusion: prevalence of diabetes in most populations is 8 - 10 %. If diabetes occurs in someone, risk of development of diabetes will increase to 30% in their family members. Therefore, screening must be done in all family members of diabetic patients to recognize the problem and to prevent from diabetes complication