ABSTRACT
In this study an Ayurvedic formulation Mahadraksharista was studied for its pharmacological properties using laboratory mice. There was a constant reduction in food and water intake in Mahadraksharista treated mice, consequently there was also a reduction in urine volume, stool and water content of stool. The Mahadraksharista in a significant extent reduced the intestinal motility. This reduced intestinal motility was further supported by the significant anti-diarrhoeal property of the preparation in castor oil induced diarrhoea test. The formulation markedly increased the latent period of diarrhoea and reduced the purging index value. The Mahadraksharista significantly reduced the onset of sleeping time, but had no effect on the duration of sleeping time
ABSTRACT
Pharmacological effect of the drug Rasaraja Ras [RRR] was studied using albino mice. RRR reduced both spontaneous motor activity and, amphetamine induced hyperactivity. Conclusion from open field test, hole cross test, hole board test and climbing out test suggest a CNS depressant activity. But RRR did not potentiate pentobarbital sleeping time and it did not show any neurotoxicity or marked ataxia at this dose level. RRR exhibited analgesic activity and it lowered both the normal rectal temperature and pectin induced hyperthermia. On 24-hour metabolic studies RRR revealed reduction in food and water intake and also in defaecation. In 30-day growth study a dose dependent reduction in body weight gain was revealed
ABSTRACT
The pharmacological effects of Nabayas Louha [NBL], an Ayurvedic haematinic preparation was investigated in animal models. It was observed that NBL possesses a significant level of Central Nervous System [CNS] depressant activity in that it significantly decreased the spontaneous motor activity, and also lowered the exploratory behavior of the treated animals in hole board, open field and climbing out test. NBL also exhibits significant effects on pentobarbital induced narcosis. It was observed that Nabayas Louha significantly [p>0.05] increased the body weight of the treated animals on chronic administration
ABSTRACT
Hot water extract of Ocimum sanctum L. [Labiateae] showed bioactivity against brine shrimp lethality bioassay. The LC50 value was found l35micro g/ml and the ED50 value was calculated l3.5micro g/ml. The extract was ineffective on wheat rootlet growth inhibition bioassay. O. sanctum showed dose related antimicrobial activity against some clinical bacterial isolates Escherichia coli, Staphylococcus aureus and Salmonella typhi but failed to exhibit activity against Pseudomonas aeruginosa and Klebsiella pneumoniae
Subject(s)
Lamiaceae , Anti-Infective AgentsABSTRACT
Symplocos racemosa Roxb. is a medicinal plant widely used by the traditional practitioners in various disease conditions as single or in compounds, known as Lodh tree or Lodh Pathani. Effect of the aqueous extract of the stem-bark of Symplocos racemosa Roxb. [SRR] on food and water intake was studied using Swiss Webster mice. On a 24-hour metabolic studies SRR reduced the food and water intake and also the urination and the defaecation. For the toxicological study the alcoholic extract of the bark was used and Sprague-Dawley rats were used as experimental animal. In a 21-day long growth study no effect on the body weight gain was revealed. The administration of the alcoholic extract of SRR significantly reduces the weight of the male liver and increases the weight of the heart of both the male and the female rats significantly. It slightly increases the weight of the ovary and significantly increases the weight of the caput epididymidis but did not have any notable effect on other male sex organ weights. There were no other notable changes in the weight of other organs. A total of 28 tissues were subjected to histological evaluation. Of these, a gross histological change was observed in the kidneys. In the liver and thymus there were slight histological changes. No histological abnormalities were found in the rest of the tissues