ABSTRACT
<b>Objective: </b>Recently, use of health foods and supplements, as well as the amount of information available about them, has been steadily increasing. Therefore, a noticeable increase in adverse drug reactions caused by health foods and supplements has also been seen. The purpose of this study was to clarify the current status and backgrounds of patients with health food- or supplement-related adverse health effects.<br><b>Methods: </b>We selected the cases of health food- or supplement-related adverse health effects from the Case Reports of Adverse Drug Reactions and Poisoning Information System (CARPIS) database, which contains over 57,000 case reports of adverse drug reactions. We investigated the background, suspected products and adverse events in each case and conducted univariate logistic regression analysis to determine significance.<br><b>Results: </b>We obtained a total of 327 cases consisting of 103 causative products. Women comprised 66% of study subjects and had a significant association with dietary supplements. Patients with a history of liver disease had a significant association with liver damage caused by “Ukon,” a drink made from turmeric root and sold as an anti-hangover remedy in Japan.<br><b>Conclusion: </b>The causative products had several unique features. This information should be utilized to prevent health food- and supplement-related adverse health effects in the future.