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1.
Journal of Sheikh Zayed Medical College [JSZMC]. 2016; 7 (3): 1016-1019
in English | IMEMR | ID: emr-182073

ABSTRACT

Background: hypothyroidism is one of the common complications among beta thalasemia


Objective: to determine the frequency of hypothyroidism in patients of beta thalassemia major in Thalassemia center, Rahim Yar Khan


Methodology: study design: Single center cross-sectional study. Place and duration of study: This study was carried out in "Thalassemia Center", Sheikh Zayed Hospital, Rahim Yar Khan over a period of one year from 1[st] January to 31[st] December 2015. This study was carried out on 144 patients of thalassemia major aged 5-16 years. The data was collected regarding demographic variables, serum ferritin, T4 and TSH and duration of transfusion. The data was entered and analyzed by using SPSS version 19


Results: hypothyroidism was found in 45 [31.2%] patients. Of these, 42 [93.3%] had sub clinical hypothyroidism [normal T4 level with elevated TSH] whereas only 3 [6.7%] patients has overt hypothyroidism [decreased T4 level with elevated TSH]. Frequency of hypothyroidism has significant association with patient's age and duration of transfusion


Conclusion: sub clinical hypothyroidism occurs in a significant proportion of thalassemia major patients. Frequency of hypothyroidism has significant association with age and duration of transfusion. Regular follow-up of thalassemic patients to detect and timely treat such complication could improve the quality of life of these patients

2.
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2011; 21 (8): 487-490
in English | IMEMR | ID: emr-109638

ABSTRACT

To determine the frequency of clinical features of Celiac disease [CD] and Celiac crisis in children. Case series. Paediatrics Unit, Sheikh Zayed Medical College and Hospital, Rahim Yar Khan, from September 2009 to September 2010. Forty children aged between 4 to 13 years of either gender, presenting with complaints of recurrent diarrhea, abdominal distention, severe emaciation and dehydration were included. The information about breast feeding, weaning diets, age of introduction of wheat diets, onset of diarrhea, characteristics and frequency of stools, growth, vaccination status, symptoms in 1st degree relatives, restriction of Gluten diet in the past and anthropometric measures were recorded. Serological tests against anti-Tissue Transglultaminase [anti-tTG] antibodies were obtained in all cases. Upper gastrointestinal endoscopies were performed and multiple biopsies were taken from distal parts of duodenum. Among the forty children, twenty four [60%] were females and 16 were males [40%]. The mean age was 6.35 +/- 2.83 years. Thirty five [87.5%] parents were cousins. Breast feeding was not exclusively given and the Gluten containing weaning diets were given as early as 3.5 months of age. Thirty [75%] children presented with typical sign and symptoms of CD. Celiac crisis presented with profuse diarrhea, severe dehydration; abdominal distention; pedal edema, carpopedal spasm due to tetany; wasted muscles; head drop and inability to stand. The serum TtG antibodies in thirty-eight cases [95%] were above the cut off level of 7u/ml ranging from 35-99 u/ml. The histopathology of specimens from distal duodenum revealed lesions of M3 type in thirteen [32.5%] and M2 type in eighteen cases [45%]. All cases recovered and improved on follow-up after strict adherence to gluten-free diet [GFD]. Majority of children with Celiac disease presented with typical symptom, while Celiac crisis was characterized by severe dehydration, weakness and calcium deficiency signs. Most were the product of consanguineous marriages and were given Gluten - containing weaning foods as early as the 4th month of life


Subject(s)
Humans , Male , Female , Child , Diarrhea , Emaciation , Dehydration , Biopsy , Glutens
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