ABSTRACT
Background: Gastric cancer is the fifth most common malignancy worldwide and the third leading cause of cancer death. Gastric cancer is one of the most common malignant tumors of the gastrointestinal tract, and it poses a serious threat to people’s survival. Objective: The aim of the study to evaluate the short-term outcomes of Uncut Roux-en-Y Gastrojejunostomy for distal gastric cancer.Material & Methods:This observational study was conducted in the Department of surgical oncology, National Institute of Cancer Research and Hospital, Mohakhali, Dhaka. A total number of 51 cases were included for the study. Purposive sample technique was used. All patients received prophylactic antibiotic using cefuroxime just before the induction of anaesthesia and continued postoperatively for 5 days. All the data were analyzed statistically by using Statistical Package for the Social Sciences (SPSS-26).Results:The mean age of the study subject was 58.58±9.85 years. Majority (42%) of the study subjects were in 51-60 years age group. Among the study cases 37 (74%) were male and 13 (26%) were female. The mean total operation time was 173.70±20.35min. The mean estimated blood loss was 174.30±40.67 ml. The mean time of first flatus pass after operation was 2.08±0.75 days and the mean duration of hospital stay was 9.64±2.67 days. Post-operative complications were observed among 08 (16%) cases. The mean preoperative Hb level of the study subjects was 10.86±0.61 gm/dl and the mean preoperative albumin level of the study subjects was 3.76±0.61 gm/dl. Two patients were lost at final follow up (at 6 months). Among these 48 cases at final follow up poor outcome was observed among 15.69% cases. Conclusions:After analyzing the results of present study, it can be concluded that Uncut Roux-en-Y Gastrojejunostomy is a safe and favorable procedure for treatment of distal gastric cancer.
ABSTRACT
Chitinases (designated as SPCs) were isolated from „Shilbilati‟ potatoes, a potato prototype cultivated in Bangladesh by affinity chromatography on a chitin column. SPCs agglutinated rat erythrocytes at the minimum concentration of 7 μg/mL and showed toxicity against brine shrimp nauplii with the LC50 value of 20 μg/mL. The chitinases also agglutinated seven bacterial strains among the twelve as studied. Pseudomonas aeruginosa, Bacillus subtilis and Salmonella typhi were the most sensitive towards the SPCs and were agglutinated at 1.2, 2.5 and 5.0 μg/mL protein concentrations respectively. Antibacterial tests demonstrated that SPCs showed inhibitory activity against the pathogenic bacteria Staphylococcus aureus, Bacillus subtilis and Salmonella typhi. Antifungal activity was investigated by the disc diffusion method. Five fungal species (Candida albicans, Aspergillus niger, Fusarium vasinfectum, Aspergillus fumigatus and Aspergillus flavus) and two fungal genus (Penicillium and Mucor sp.) were examined in the assay. SPCs showed antifungal activity against Candida albicans, Fusarium vasinfectum and Penicillium sp.