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Femina ; 39(9)set. 2011.
Article in Portuguese | LILACS | ID: lil-641389

ABSTRACT

As taxas de prematuridade não atingem quedas significativas, mesmo em países desenvolvidos, alertando os pesquisadores a buscarem alternativas clínico-farmacológicas na prevenção desta enfermidade obstétrica. A matriz extracelular ocupa espaço relevante na maturação cervical, e seu entendimento é fundamental para possíveis ações preventivas. Destaca-se a provável correlação dos níveis locais de glicosaminoglicanos na prevenção do parto prematuro por inibir processos inflamatórios na cérvice uterina


The preterm delivery rates do not decrease significantly, even in developed countries, prompting researchers to seek pharmacological and clinical alternatives to prevent this obstetrics disorder. The extracellular matrix is important in cervical length, and its understanding is essential for possible preventive actions. We emphasize the probable correlation of the local levels of glycosaminoglycans to prevent premature labor by inhibiting inflammatory processes from uterine cervix


Subject(s)
Humans , Female , Pregnancy , Cervical Ripening , Glycosaminoglycans/administration & dosage , Extracellular Matrix/physiology , Extracellular Matrix/metabolism , Premature Birth/prevention & control , Infant Mortality , Urinary Tract Infections/drug therapy , Obstetric Labor, Premature/epidemiology
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