ABSTRACT
BACKGROUND: This study aimed to explore demographic characteristics and clinical presentations of celiac disease [CD] in Northeastern Iran
METHODS: This was a cross-sectional retrospective study of 193 adults with CD who presented to Mashhad University Gastroenterology Clinic between 2008 and 2013. Patient data that included mode of presentation and the presence of any concomitant illnesses were collected. Intestinal biopsy and serum anti-tissue transglutaminase [anti-tTG] were used for diagnosis. Mucosal lesions were classified according to modified Marsh classification
RESULTS: Overall, 132 females and 61 males, with a mean age at diagnosis of 32.6 +/- 13.2 years were included
The patient's chief complaints in order of decreasing frequency were dyspepsia [24.6%], diarrhea [20%], anemia [12.8%], and flatulence [7.2%]
Bone disease was seen [osteopenia, osteoporosis] in 30% of patients
A positive family history of CD was found in 17.9% of cases
There were 64% who had serum anti-tTG >200 units/ml and 78% had a Marsh classification grade 3 on duodenal biopsy
The histology grade [Marsh] did not show any correlation with anti-tTG serum levels, age, body mass index [BMI] or hemoglobin levels
CONCLUSION: In Northeastern Iran, CD was seen more commonly in females and with non-diarrheal presentations. Abdominal discomfort, anemia and bone disease were most common primary presentations in this area. Histology grade showed no significant correlation with level of anti-tTG, BMI or hemoglobin levels
We suggest screening for CD in unexplained abdominal discomfort, bone disease and anemia