ABSTRACT
Background: DOX is one of the most common drugs used to treat different types of cancer, including testicular cancer. The aim of this study was to evaluate the effect of ethanol extract of ginger on spermatogenesis in rats
Materials and methods: In this experimental study, 56 male rats Wistar were randomly divided into 6 groups of 8 animals control, the sham and experimental group 1 receiving doxorubicin [mg/kg.bw 3] experimental 2 and 3 receiving ginger extract [500, 1000 mg/ kg. bw ] and experimental 4 and 5 received a ginger extract [500, 1000 mg/ kg. bw ] + doxorubicin. The rats were fed extract daily, one hour after doxorubicin injection, for four weeks. DOX [3mg/kg] was administered once a week intraperitoneally. Some sperm parameters, such as the number, viability, morphology and mobility were examined using Eosin-Ngrozin staining
Results: A significant decrease in body weight, sperm count, sperm motility, viability was observed in drug-DOX-treated rats compared with the control group. The reduction in the group treated with DOX with ginger 500 and 1000 mg/ kg significantly was offset compared with DOX
Conclusion: Ginger is able to have protective effect on sperm parameters in adult male rat induced by Doxorobicin