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1.
Medical Journal of Tabriz University of Medical Sciences and Health Services. 2016; 38 (1): 44-49
in Persian | IMEMR | ID: emr-181858

ABSTRACT

Background and Objectives: Although the etiology of multiple sclerosis [MS] - a chronic autoimmune disease of the central nervous system - has not been well understood, the role of environmental factors, particularly the lack of vitamin D has recently been considered. Therefore, this study was aimed to compare the intake of food containing vitamin D between the MS patients and healthy individuals


Materials and Methods: This case-control study was carried out on 168 MS patients randomly selected from MS Society of East Azerbaijan province in Tabriz and 168 age and sex - matched apparently healthy individuals from relatives of the MS subjects or healthy volunteers in December 2012 - March 2013. Data regarding the consumption of food containing vitamin D, were obtained through completing a semi quantitative food frequency questionnaire and face-to-face 3-day food records by a trained interviewer


Results: Although the weekly frequency consumption of fat group did not show any significant differences between the groups, weekly frequency consumption of meat group, daily products and miscellaneous foods such as hamburgers, bolognia, sausages, and fresh mushrooms in healthy volunteers were significantly higher than MS patients [P<0.05]. Inadequate dietary vitamin D among the MS patients was approximately three-fold more common than healthy subjects [P=0.041]


Conclusion: Our finding indicate the inadequacy of consumption of vitamin D containing foods among MS patients which probably reveal the necessity of nutrition education and vitamin D supplementation in MS

2.
Neurosciences. 2008; 13 (4): 359-362
in English | IMEMR | ID: emr-89265

ABSTRACT

To investigate homocysteine levels in Alzheimer's disease and its relationship with the severity of disease. This investigation was performed as a case-control study on 40 Alzheimer patients and 40 non-Alzheimer patients in Tabriz, Iran from May 2006 to September 2007. Alzheimer patients were selected based on the criteria of the American Psychological Association. The severity of illness was determined based on Reisberg scale. Mental status of the patients was evaluated by Mini Mental State Examination [MMSE]. The serum levels of homocysteine were measured by enzyme-linked immunosorbent assay method. The average serum homocysteine level in the 40 patient group was 23.01 +/- 14.40mmol/L, and in the 40 patient control group was 15.40 +/- 6.23 [p=0.003]. The average serum homocysteine level in the first group of patients was 21.7 +/- 12.7mmol/L, in the second group 22.3 +/- 13.8, and in the third group 24.9 +/- 17.2. The relationship between MMSE score and serum homocysteine level of patients was not significant [p=0.4]. The average serum homocysteine level in Alzheimer patients was higher than in the control group, however, it did not show a significant relationship with the severity of illness


Subject(s)
Humans , Male , Female , Homocysteine/blood , Case-Control Studies , Enzyme-Linked Immunosorbent Assay
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