Granuloma faciale with disseminated extrafacial lesions

Granuloma faciale [GF] is a rare cutaneous disorder categorized as a localized form of small-vessel vasculitis. Clinically, it manifests as single or multiple well-demarcated red-brown plaques, papules and nodules, nearly always confined to the face. Herein, we report a 39-year-old man with multiple red-brown infiltrated plaques on face and extrafacial lesions on back, shoulders and both arms. Skin biopsy revealed typical histopathological findings of GF. The patient failed to respond to pulsed dye laser but intralesional triamcinolone combined with cryotherapy led to an acceptable response

Interplay among antioxidants and oxidants in psoriasis

The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected. The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients. Forty two psoriatic patients and 42 age and sex matched controls were recruited for this study. Serum total antioxidant capacity [TAC], oxidized light density lipoprotein [Ox-LDL] and malondialdehyde [MDA] levels were determined. A statistically significant increase in the serum level of MDA was found between patients and controls. No significant difference was found in the serum levels of other parameters in the two groups. Our results supported the hypothesis of an imbalance between oxidants and antioxidants in psoriasis and pointed to the probability of an increased risk of cardiovascular diseases in psoriatic patients