ABSTRACT
Obesity increases cardiac diseases by increasing tendency to atherosclerosis. Our aim was to define epicardial adipose tissue thickness, and its related factors in obese children. Total of 94 patients were divided into obesity with metabolic syndrome [MS] [n=30], obesity without MS [n=33], and control [n=31] groups. Auxological values with fasting glucose, fasting insulin, alanine transaminase, serum lipid levels, and high sensitive C-reactive protein levels were evaluated. Epicardial adipose tissue thickness, interventricular septum thickness and left ventricular mass were measured by echocardiography. Weight, body mass index, waist circumference, insulin, alanine transaminase, and high sensitive C-reactive protein values were markedly higher in obesity group when compared with controls [P<0.001]. Epicardial adipose tissue thickness was 0.64 +/- 0.23 cm in obesity with MS; 0.60 +/- 0.20 cm in obesity without MS, and 0.27 +/- 0.12 cm in control group [P<0.001]. Interventricular septum thickness and left ventricular mass values were markedly high in obesity without MS group [P<0.001 and P=0.002]. Our study has indicated that obesity has unfavorable effects on heart starting in the adolescence
ABSTRACT
OBJECTIVE: This work investigates the role of glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), and glutathione S-transferase P1 (GSTP1) enzymes and polymorphisms, which are found in phase II detoxification reactions in the development of cervical cancer. METHODS: This study was conducted with 46 patients diagnosed with cervical cancer and 52 people with no cancer history. Multiplex PCR methods were used to evaluate the GSTM1 and GSTT1 gene polymorphism. However, the GSTP1 (Ile105Val) gene polymorphism was studied using a PCR-RFLP method. The patient and control groups were compared using a chi-square test with p0.05). CONCLUSION: Our results demonstrate that GSTT1, GSTM1, and GSTP1 polymorphisms are not associated with cervical cancer in Turkish patients.