ABSTRACT
The liver is an organ at risk [OAR] in radiotherapy of thoracic and abdominal tumors such as gastric, distal esophagus, lower lung and breast, bile duct, pancreas and whole abdomen. In this study the alteration in liver functional tests [LFT] of these patients during radiotherapy was investigated. To that end, the level of serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP], direct and total bilirubin were checked out at different times [before radiotherapy and every 2 weeks after the start of radiotherapy and followed up to 2 months after the end of treatment]. The results showed that LFT level increased during radiotherapy while they gradually decreased after treatment. Our results showed that the LFT serum is a very sensitive and useful biomarker for evaluation of the radiotherapy effects