Comparison efficacy of Curosurf and Survanta in preterm infants with respiratory distress syndrome

This study aim was to compare the therapeutic efficacy of Curosurf and Survanta in preterm infants which were admitted into NICU. In this interventional study, 150 preterm infants divided randomly in two groups [75 in Survanta and 75 in Curosurf]. Data analyzed by statistical methods in SPSS.19. The significance level was considered to be P<0.05.There were no statistically significant differences in gestational age, birth weight, mortality rate, pneumothorax, Brunch-Pulmonary Dysplasia [BPD], Intra Ventricular Hemorrhage [IVH] and the mean duration of hospitalization between two groups. But in repeating dose of Survanta group with 67.7% was higher than Curosurf group with 32.3% [p=0.043] and in mean duration of ventilation Survanta group with 8 days was lower than Curosurf group with 10.5 days [P=0.001]. Results showed in treatment of RDS in preterm infants each of two groups had similar sideeffects but the need for repeated doses in Curosurf group and need for ventilation in Survanta group is less than others

Prevalence and risk factors associated with preterm birth in Ardabil, Iran

Preterm birth is a leading cause of perinatal mortality and long-term morbidity as well as the long-term health consequences and cognitive outcomes. Present study was conducted to determine prevalence and risk factors associated with preterm birth in Ardabil, Iran. A case control study was conducted between Nov 2010 and July 2011 in all three maternal hospitals in Ardabil. All the live newborns during the study period were investigated. Of 6705 live births during the study period 346 births occurred in <37 weeks were taken as a case and 589 term neonates were taken as a control group. Data were obtained through review of prenatal and hospital delivery records. Univariate and multivariate logistic regression analysis were applied to obtain magnitude of association between independent variables and preterm birth. The prevalence rate of preterm birth was 5.1%. History of previous preterm birth [OR=12.7,CI: 3.9-40.4, p<0.001], hypertension [OR=7.3, CI:2.1-25.4, p=0.002], Oligohydramnios [OR=3.9, CI:1.6-9.5, p=0.002], spouse abuse [OR=3.7, CI:1.1-11.8, p=0.024], preeclampsia [OR=3.6, CI:1.3-10.3, p=0.014], premature rupture of membrane [OR=3.1, CI:1.9-4.9, p=0.000], bleeding or spotting during pregnancy [OR=2.0, CI:1.0-3.8, p=0.037], Hyperemesis Gravid arum [OR=2.0, CI: 1.1-3.8, p=0.015], urinary tract infection in 26-30 weeks, [OR=1. 8 CI:1.0-3.2, p=0.04], diastolic blood pressure

Prevalence and risk factors for low birth weight in Ardabil, Iran

Introduction Low birth weight [LBW] is the most common cause of neonatal death in developing countries. The objective of our study was to determine the prevalence and risk factors associated with low birth weight in Ardabil, Iran from 2010 to 2011. In a case-control study all live newborns were weighted without clothing using a standard calibrated scale. Gestational age was calculated using either the first day of the last normal menstrual period or estimated by obstetric sonography. 358 neonates with birth weight of less than 2500 g were considered as case and 705 normal weight neonates as control groups. Data were collected through a self-designed questionnaire from review of prenatal and hospital delivery records. Kruskal -wallis, chi-square, and logistic regression were applied to analyze data using SPSS version 16. Incidence of LBW was 6.3% and among these, 84.2% were preterm and 15.8% had intrauterine growth retardation. Hypertension [OR:8.64, CI: 2.63-28.31], multiple pregnancy [OR: 7.62, CI:3.09-13.32], leakage [OR:4.46, CI: 2.11-9.42], Oligohydramnios [OR:4.28, CI:1.90-9.76],history of preterm birth [OR:2.84, CI: 1.20-6.71], bleeding or spotting during pregnancy [OR:2.36,CI:1.41-3.95] were determined as important risk factors for preterm LBW. Risk of low birth weight in term infants increased by multiple pregnancy [OR:3.77, CI: 1.41-10.0], bleeding and spotting [OR:2.23, CI:1.22- 4.07],and urinary tract infection in weeks 26-30 of pregnancy [OR:2.42, CI :1.11-5.26]. Delivering quality health care for all pregnant women and early diagnosis and control of hypertension, urinary tract infection, and bleeding or spotting and leakage during pregnancy may significantly reduce the rate of low birth weight and improve public health in this area

Heart murmur in neonates: how often is it caused by congenital heart disease?

Congenital heart disease [CHD] is the most common form of cardiovascular diseases in children. This study was performed from September 2006 to August 2007 in Ardebil, Westnorthern Iran. The aim was to determine the prevalence of heart murmur in newborns and its correlation with CHD. In a 1-year cross sectional descriptive-analytic study, 2928 newborns were screened for heart murmur during routine neonatal physical examination. All babies with murmur underwent echocardiography. Murmur was detected in 91 [3.1%] neonates, of whom 47 [51.6%] had a congenital heart disease. The most common [17.6%] abnormality was ventricular septal defect. Patent ductus arteriosus was found in 10 [11%] patients. Remarkable high [round 50%] rate of CDH in newborns presenting with heart murmur, urges to observe these neonates closely to establish the diagnosis of congenital heart disease and early referral to pediatric cardiologist