ABSTRACT
This study was conducted to determine the effect of fish oil [FO] supplements on high density lipoprotein cholesterol [HDL-C], apolipoprotein-Al [Apo-Al], malondialdehyde [MDA], arylesterase [Aryl], and paraoxonase-1 [PON1] activity in female patients with rheumatoid arthritis [RA]. A total of 90 RA patients were randomly allocated into two groups that were treated with one FO pearl [1 gr] daily or placebo for three months in addition to conventional treatment. HDL-C, Apo-Al, and MDA levels as well as POW and Aryl activities were measured before and after treatment. Independent t-test was used to match basal parameters of case and control groups. Paired t-test was used to assess significance of the differences. Correlation was evaluated by Pearson's test and the statistical significance was set at P < 0.05. No significant differences were noted between FO and placebo patients with regards to age, disease duration, post-menopausal status, conventional therapy, body mass index [BMI], and numbers of swollen and tender joints at the beginning of the study. There were 83 patients who completed the three-month follow up. Serum levels of HDL-C [P = 0.018], Apo-Al [P = 0.165], Aryl [P = 0.026], and POW [P = 0.049] activity increased, whereas MDA levels decreased significantly with FO supplementation [P= 0.077]. Significant correlations between increased POW activity and both HDL-C [P = 0.007, r = 0.419] and Apo-Al [P < 0.001, r = 0.742] concentrations as well as between HDL-C and Apo Al levels [P= 0.01, r = 0.403] were found. According to the results of this study, EQ could increase serum HDL-C and PQN1 levels and Aryl activity in female patients with RA
ABSTRACT
A 20-year-old woman was admitted to a Gynecology Hospital in her 6[th] month of pregnancy for high blood pressure and tonic-clonic seizure. Primary diagnosis was eclampsia, and for that reason she underwent cesarean section. She also had headache on frontal and parietal areas without nausea or vomiting. There was not a focal neurological sign. Rheumatology consultation was requested. Systemic lupus erythematosus and secondary antiphospholipid [APS] was confirmed. The patient had headache that continued several days after cesarean section, therefore, brain magnetic resonance imaging [MRI] and magnetic resonance venography [MRV] were performed, and cerebral vein thrombosis was documented. Distal segment of right lateral sinus and sigmoid sinus were not appeared in brain MRV. Abnormal hypersignal intensity of right lateral sinus/coronal T2 was detected. Thrombolytic therapy with 20 mg tissue plasminogen activator on right sigmoid and transverse sinus was performed by an interventional neurologist. After this procedure, the patient's headache healed and she was discharged in a good condition