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Objective To investigate the relationship between the serum levels of leptin, neuron-specific enolase (NSE) and S-100B in patients of stroke and the incidence of post-stroke depression (PSD). Methods The clinical data of 121 cases of acute ischemic stroke, admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University from Jun. 2010 to Dec. 2012, were retrospectively analyzed. After six months of follow-up 42 patients were diagnosed as suffering from PSD (Hamilton Depression Scale score ≥8). Another 42 participants with available matching data on onset time, age, gender and lesions of brain were selected. The serum samples were collected from all patients at time of discharge, and the concentrations of serum leptin, NSE and S-100B were analyzed by enzyme-linked immunosorbent assay (ELISA) kit. Correlation and efficiency of diagnosing PSD among them was validated by receptor operator curve (ROC). Results The concentration of serum leptin, NSE, and S-100B in PSD group (25.84±13.80, 2.59±1.48 and 25.03±8.24μg/L, respectively) was higher than that in the control group (8.67±6.17, 2.27±1.84 and 22.40±6.84μg/L, respectively). No obvious correlation was found between serum leptin and the NSE and S-100B in PSD patients. Based on the ROC curve, the area under the curve of serum leptin in PSD patients was 0.935 (95%CI 0.885-0.984), and the optimal cutoff value of serum leptin level was 16.17μg/L, which was an indicator for predicting of PSD with 81.0% sensitivity and 90.1% specificity. Conclusion Elevation of serum leptin level at admission was found to be associated with PSD, and it may act as a new marker for predicting the occurrence of PSD.
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<p><b>OBJECTIVE</b>To study the relationship between the mesiodistal tipping degree of maxillary and mandible posterior teeth and different vertical facial skeletal types of subjects with normal occlusion.</p><p><b>METHODS</b>163 subjects with normal occlusion were selected, lateral cephalograms were taken and divided into three different facial skeletal types. The difference of the mesiodistal tipping degrees and intersection angles of upper and lower posterior teeth between the three different facial skeletal types were analyzed.</p><p><b>RESULTS</b>Among 163 subjects, vertical growth pattern, average growth pattern and horizontal growth pattern were 24, 96 and 43 respectively. There were statistic differences of mesiodistal tipping degrees of the first and second maxillary and mandible premolar and the first permanent molar between vertical growth and horizontal growth pattern, horizontal growth and average growth pattern (P < 0.05). But there were no statistically significant differences between vertical growth and average growth pattern (P > 0.05). The differences of the maxillary and mandible posterior teeth's intersection angle among three vertical facial skeletal types had no statistic significance (P > 0.05).</p><p><b>CONCLUSION</b>Different vertical facial skeletal type has its own normal and coordinated posterior teeth mesiodistal tipping degrees.</p>
Subject(s)
Humans , Dental Occlusion , Mandible , Maxilla , ToothABSTRACT
<p><b>OBJECTIVE</b>To figure out the differences of the morphological characteristics of mandibular symphysis between Class II and Class III adult skeletal malocclusions with different abnormal vertical skeletal patterns.</p><p><b>METHODS</b>109 Chinese female adults of skeletal Class II and Class III were chosen and divided into four groups according to vertical and sagittal skeletal pattern: Class II--vertical-growth-pattern group (n=30), Class III--vertical-growth-pattern group (n=25), Class II--horizontal-growth-pattern group (n=29), Class III--horizontal-growth-pattern (n=25). Lateral cephalograms were taken. The symphyseal widths and heights, along with lower incisor positions were evaluated. Observation and statistics analysis were done to clarify the morphological characteristics of the symphyseal region of different skeletal patterns.</p><p><b>RESULTS</b>There were morphological differences of symphyseal region between Class II and Class III skeletal malocclusions, but not significant in width and total height. With a vertical-growth-pattern, Class II malocclusions had higher alveolus than Class III, but smaller chin prominence and lower basal bone (P < 0.01). With a horizontal-growth-pattern, Class II malocclusions had higher alveolus (P < 0.05) and larger alveolar top width (P < 0.001). With a same sagittal skeletal pattern, vertical-growth-pattern group had thinner but higher symphyseal region and bigger chin prominence (P < 0.001 in Class II while P < 0.05 in Class III). Besides, a vertical-growth-pattern malocclusion was prone to have a cucurbit-morph chin, of which Id width was larger than basal width (P < 0.01).</p><p><b>CONCLUSION</b>There are morphological differences in symphyseal region between Class II and Class III skeletal malocclusions with different abnormal vertical skeletal patterns. The influence of abnormal vertical skeletal pattern to symphyseal morphological characteristics is greater than that of abnormal sagittal skeletal pattern. There is a risk of orthodontic movement of low incisors in vertical-growth-pattern skeletal malocclusion.</p>
Subject(s)
Adult , Female , Humans , Malocclusion, Angle Class II , Pathology , Malocclusion, Angle Class III , Pathology , Mandible , PathologyABSTRACT
<p><b>OBJECTIVE</b>To study the incisal jaw morphology of subjects with normal occlusion and to discuss the relationship between different vertical facial skeletal types and different incisal jaw cluster types.</p><p><b>METHODS</b>After studied by radiographic cephalometry, the incisal jaw morphology of 169 subjects with normal occlusion in early permanent dentition were analyzed by K-mean cluster analysis.</p><p><b>RESULTS</b>Morphology of maxillary or mandibular incisal jaws could be divided into four types separately, including division I, division II, division III and division N. In maxilla or in mandible, the incisal jaw morphology of division I was characterized by wideness and shortness. In contrast, division II was characterized by thinness and length. As for division III and division IV, both of two were intermediate types between division I and division II . In maxilla, it was found that division II was the majority (86.49%) in the high-angle subjects, division III was the majority (47.67%) in the average-angle subjects, and division I and III were the majority (82.61%) in the low-angle subjects. In mandible, it was found that division II was the majority (51.35%) in the high-angle subjects, division IV was the majority (48.84%) in the average-angle subjects, and division III and IV were the majority (69.57%) in the low-angle subjects.</p><p><b>CONCLUSION</b>Owing to the obvious characteristics of morphology in each cluster types and in each vertical facial skeletal types, different clinic considerations must be put forward when we want to move the incisor.</p>