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Objective To investigate changes and the clinical significance of serum 25-Hydroxyvitamin D level in patients of Xinjiang Uygur and Han nationalities with mild cognitive impairment.Methods On the base of early stage of epidemiological survey of Xinjiang Uygur and Han population over 60 years old,adopting multi-stage stratified random cluster sampling method and referencing DSM-Ⅳ,206 cases of MCI patients (study group)were selected and 412 healthy elderly subjects (control) matching for age,nationality and gender were recruited for case-control study.The serum level of 25(OH) D was measured by enzyme-linked immunosorbent assay (ELISA).Results The serum level of 25(OH)D was significantly lower in MCI group of two nationalities (7.89±0.29 μg/L) than in normal control group [(8.65± 0.21) μg/ml,P＜0.05].The serum level of 25(OH)D was (8.41±0.34) μg/L in Han group,and (8.37±0.32)μg/L in Uygur group,with no significant difference (P＞0.05).The 25 (OH)D level was significantly lower in female[(8.23± 0.32) μg/L] than in male [(8.70±0.42) μg/L,P＜0.05].The serum level of 25(OH)D was lower in female MCI group [(7.56±0.34) μg/L] than in female control group [(8.41 ±0.31)μg/L],with significant difference (P＜0.05).While there was no significant difference between male MCI and male control group (P＞0.05).Multivariate Cox regression analysis showed that the risk factors of MCI might include low serum 25 (OH) D levels (OR =1.163,95 ％ CI:0.978-1.447),a decreased physical labor (OR=1.420,95％ CI:1.10-1.860),low education degree (OR =1.504,95％ CI:1.129-2.130),celibacy (OR=1.293,95％CI:0.845-1.440),hypertension (OR=1.954,95％CI:1.342-2.670),diabetes (OR =1.320,95％ CI:1.145-1.710),smoking history (OR =1.350,95％ CI:1.101-2.293),high BMI (OR=1.329,95％CI:1.068-1.781).Conclusions The serum 25(OH)D level is lower in MCI patients in Xinjiang Uygur and Han populations than in normal people,but there is no significant difference.The 25 (OH)D deficiency is associated with increased odds for cognitive impairment in the elderly Xinjiang population,which is more obvious in the female.The occurrence and development of MCI is affected by multiple risk factors.
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<p><b>OBJECTIVE</b>To assess the association of vitamin D receptor gene (VDR) Apa I, Bsm I genotypes and allele frequencies and mild cognitive impairment (MCI) among elderly ethnic Uygurs from Xinjiang, China.</p><p><b>METHODS</b>The polymorphisms of the VDR genotypes (Apa I and Bsm I) were analyzed by the SNaPshot method in 124 MCI patients and 124 controls.</p><p><b>RESULTS</b>Factors which can increase the risk for MCI have included the A allele of the Apa I polymorphism [OR=1.62, 95%CI(1.13-2.31)] and the AA genotype [OR=3.49, 95% CI(1.57-7.74)], the T allele of the Bsm I polymorphism [OR=1.94, 95%CI(1.24-3.05)], higher triglyceride and systolic blood pressure levels.</p><p><b>CONCLUSION</b>Polymorphisms of the VDR gene including the A allele and AA genotype of Apa I, and the T allele of Bsm I are probably associated with MCI among elderly ethnic Uygurs, and so are higher levels of triglyceride and systolic blood pressure.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Alleles , Asian People , Genetics , Binding Sites , Genetics , Blood Pressure , China , Cognitive Dysfunction , Ethnology , Genetics , Psychology , Deoxyribonucleases, Type II Site-Specific , Metabolism , Diagnostic and Statistical Manual of Mental Disorders , Ethnicity , Genetics , Gene Frequency , Genetic Predisposition to Disease , Ethnology , Genetics , Genotype , Logistic Models , Multivariate Analysis , Polymorphism, Single Nucleotide , Receptors, Calcitriol , Genetics , Triglycerides , BloodABSTRACT
@#Objective To investigate the level of plasma total homocysteine(Hcy),the carotid intima-media thickness(IMT)and relationship of the plasma Hcy and carotid atherosclerosis in hypertensive patients.Methods Sixty patients with hypertension and sixty health controls were measured for carotid IMT and the level of plasma total Hcy.Results The level of plasma total Hcy and the carotid IMT in hypertensive patients increased significantly compared with that of the controls.The level of plasma total Hcy increased with the severity of the carotid plaque.The carotid IMT was correlated with age,cholesterol,low-density cholesterol,systolic blood pressure(P<0.05 or P<0.01).Conclusion The average carotid IMT is correlated with the level of plasma Hcy in hypertensive patients;the level of plasma total Hcy,age,cholesterol,low-density cholesterol,systolic blood pressure are the important risk factors of carotid atherosclerosis.