ABSTRACT
Graft-versus-host disease (GVHD) is one of the major complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which seriously affects the prognosis of patients. At present, a new regimen of post-transplantation cyclophosphamide (PTCy) combined with antithymocyte globulin (ATG) has been used to prevent GVHD, indicating that PTCy combined with ATG may have a good effect on the prevention of GVHD in different types of transplantation. However, the mechanism of this regimen, its effect on immune reconstitution and viral reactivation still needs to be further studied. Therefore, this article briefly reviews the research progress of PTCy combined with ATG in preventing GVHD after HSCT.
Subject(s)
Humans , Antilymphocyte Serum , Cyclophosphamide , Hematopoietic Stem Cell Transplantation/adverse effects , Graft vs Host Disease/prevention & control , Transplantation, Homologous , Retrospective StudiesABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of apoptosis in the remodeling of temporomandibular joint (TMJ) under pressure.</p><p><b>METHODS</b>Synovial fibroblasts obtained from rat temporomandibular joint were subjected to different hydrostatic pressure for 12 h. Changes of ultrastructure were observed by transmission electron microscope.</p><p><b>RESULTS</b>At 30 kPa, the ultrastructure of synovial fibroblasts showed no obvious changes. At 60 kPa, the chromatin was condensated, the baryon took on crescent and the mitochondria seemed varicose. At 90 kPa, the apoptosis-like body was wrapped by membrane and embedded in the high density chromatin.</p><p><b>CONCLUSIONS</b>Apoptosis-like change took place in ultrastructure of synovial fibroblasts under hydrostatic pressure, and the degree of the change was related to the hydrostatic pressure exerted.</p>