ABSTRACT
Objective To explore the risk factors for persistent pulmonary hypertension of the newborns (PPHN).Methods An 1 ∶ 1 matched case-control study was conducted in 41 cases of PPHN.Chi-square,t-test or ANOVA were used to perform univariate analysis.All factors for P values less than 0.05 were used as independent variables for multivariate analysis of Logistic regression,and a predictive model of Logistic regression for the genesis of PPHN was established,and the model was evaluated preliminarily.Results By multivariate analysis of Logistic regression,meconium aspiration syndrome (OR =52.391,95 ％ CI:3.899-703.959),matemal diabetes (OR =49.758,95 ％ CI:3.544-698.686),neonatal pneumonia (OR =49.637,95％ CI:6.143-401.100),intra-uterine growth restriction (OR =26.666,95％ CI:2.997-237.282),hyaline membrane disease (OR =15.200,95 ％ CI 2.862-80.726) were significantly related to genesis of PPHN.Goodness of fit for predictive model of Logistic regression was checked by Chisquare and x2 value was 23.681.It indicated model check was statistically significant (P ＜ 0.01).Conclusions Meconium aspiration syndrome,maternal diabetes,neonatal pneumonia,intra-uterine growth restriction,and hyaline membrane disease are major risk factors for genesis of PPHN.