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Objective To analyze the Oxford classification (MESTC) and the International Study of Kidney Disease in Children (ISKDC) classification for evaluating the clinical manifestations,histological lesion and short-term prognosis of children with Henoch-Sch(o)nlein purpura nephritis (HSPN).Methods According to the Oxford classification and ISKDC classification,the histological lesions of children with HSPN diagnosed by renal biopsy from Beijing Children's Hospital affiliated to Capital Medical University from January 2018 to December 2018 were re-evaluated.The renal biopsy specimens of the selected subjects were scored according to the Oxford classification and the ISKDC classification.According to whether the first symptom was combined with renal performance,MESTC score and ISKDC classification,children were grouped.The differences in clinicopathological manifestations between the groups were compared.Correlation between MESTC and ISKDC grades was analyzed by nonparametric test rank correlation.Kaplan-Meier survival curve and Log-rank test were used to compare the difference of proteinuria remission rate between the two groups.Univariate and multivariate Cox regression equations were used to analyze the influencing factors of the proteinuria remission rate.Results A total of 78 children with HSPN were enrolled.There were 37 male patients (47.4％) with age of (10.4+2.9) years.When the patients were divided according to MESTC scores and ISKDC classification,the results showed that the proportion of children with nephrotic-range proteinuria in the group of endocapillary hypercellularity (E1,P=0.008),segmental glomerulosclerosis (S1,P=0.015) and ISKDC Ⅲ (P=0.041) was higher than that of E0,S0 and ISKDC Ⅱ groups.The proportion of children with E1 (P=0.015),crescents (C1&C2,P=0.025) or ISKDC Ⅲ (P=0.017) that had been treated with high-dose methylprednisolone was higher.The result of Kaplan-Meier survival curve showed more difficult for proteinuria remission in children with C2 are than C0&C1 group (P=0.026),while no difference were found when children were grouped by M,E,S,T and ISKDC.Multivariate Cox regression analysis showed that the C2 (HR=0.143,95％C1 0.020-1.046,P=0.055) might be a risk factor for proteinuria remission,while the P value was close to 0.05.Conclusions Children with HSPN scored as ISKDC Ⅲ,E1 and S1 are more likely to show nephrotic-range proteinuria.C2 may indicate that patients are more difficult to achieve proteinuria remission.
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BACKGROUND: With the development of tissue engineering, materials science, and biomechanics, developing new biodegradable ureteral stent has become an issue of concern. The ureteral stent with poly(L-lactide-co-ε-caprolactone)/crosslinked polypyrrolidone was prepared. OBJECTIVE: To explore the histocompatibility of the ureteral stent grafted into the bladder of Sprague-Dawley rats. METHODS: Sixty male Sprague-Dawley rats (provided by Laboratory Animal Center of Sichuan Academy of Traditional Chinese Medicine) were randomly divided into four groups, each group containing 15 rats. The sham operation group was directly sutured after opening a small incision on the outside of the bladder, and no material was implanted. The other three groups were implanted with polyurethane ureteral stent (control group), poly(L-lactide-co-ε-caprolactone)/8% cross-linked polyvinylpyrrolidone ureter stent (experiment group 1), poly(L-lactide ε- caprolactone)/5% cross-linked polyvinylpyrrolidone ureteral stent (experiment group 2) after opening a small incision on the outer side of the bladder, followed by suturing the incision. At 4, 8, and 16 weeks after operation, the local anatomy of the bladder was observed. The histocompatibility of the materials in each group was observed by hematoxylin-eosin staining. The study was approved by the Ethical Committee of Laboratory Animal Analysis and Testing Center of West China School of Public Health, Sichuan University. RESULTS AND CONCLUSION: (1) Gross observation: At 4, 8 and 16 weeks postoperatively, different degrees of chronic inflammation reaction occurred in the control group and experimental group 1. In the experiment group 2, chronic inflammatory reaction appeared at 4 weeks postoperatively. The stone formation rate in the control group and experimental group 1 was significantly higher than that in the sham operation group (P 0. 05). The calculus formation rate in the experimental group 2 was significantly higher than that in the sham operation group only at 4 weeks postoperatively, and had no significant difference at other time points (P > 0. 05). (2) Pathological observation: Different degrees of foreign body in the outer membrane, inflammatory reaction and diffuse hyperplasia of the mucosa were found in the control group, experimental groups 1 and 2 at different time points postoperatively. There was no significant difference in the rate of diffuse hyperplasia of the mucosa at different time points postoperatively among groups (P > 0. 05), but higher than that in the sham operation group (P < 0. 05). (3) These results indicate that the calculus formation rate and bladder histological reaction of poly(L-lactide-co-ε-caprolactone)/cross-linked polyvinylpyrrolidone ureter stent are comparable with those of commercial ureteral stents, especially the addition of 5% cross-linked polyvinylpyrrolidone has better histocompatibility.
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Objective@#To analyze the Oxford classification (MESTC) and the International Study of Kidney Disease in Children (ISKDC) classification for evaluating the clinical manifestations, histological lesion and short-term prognosis of children with Henoch-Schönlein purpura nephritis (HSPN).@*Methods@#According to the Oxford classification and ISKDC classification, the histological lesions of children with HSPN diagnosed by renal biopsy from Beijing Children's Hospital affiliated to Capital Medical University from January 2018 to December 2018 were re-evaluated. The renal biopsy specimens of the selected subjects were scored according to the Oxford classification and the ISKDC classification. According to whether the first symptom was combined with renal performance, MESTC score and ISKDC classification, children were grouped. The differences in clinicopathological manifestations between the groups were compared. Correlation between MESTC and ISKDC grades was analyzed by nonparametric test rank correlation. Kaplan-Meier survival curve and Log-rank test were used to compare the difference of proteinuria remission rate between the two groups. Univariate and multivariate Cox regression equations were used to analyze the influencing factors of the proteinuria remission rate.@*Results@#A total of 78 children with HSPN were enrolled. There were 37 male patients (47.4%) with age of (10.4±2.9) years. When the patients were divided according to MESTC scores and ISKDC classification, the results showed that the proportion of children with nephrotic-range proteinuria in the group of endocapillary hypercellularity (E1, P=0.008), segmental glomerulosclerosis (S1, P=0.015) and ISKDCⅢ(P=0.041) was higher than that of E0, S0 and ISKDCⅡ groups. The proportion of children with E1 (P=0.015), crescents (C1&C2, P=0.025) or ISKDCⅢ(P=0.017) that had been treated with high-dose methylprednisolone was higher. The result of Kaplan-Meier survival curve showed more difficult for proteinuria remission in children with C2 are than C0&C1 group (P=0.026), while no difference were found when children were grouped by M, E, S, T and ISKDC. Multivariate Cox regression analysis showed that the C2 (HR=0.143, 95%CI 0.020-1.046, P=0.055) might be a risk factor for proteinuria remission, while the P value was close to 0.05.@*Conclusions@#Children with HSPN scored as ISKDCⅢ, E1 and S1 are more likely to show nephrotic-range proteinuria. C2 may indicate that patients are more difficult to achieve proteinuria remission.
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A large number of medical studies have confirmed that inflammation with occurrence and de-velopment of tumor are closely related. In recent years,it has been confirmed and described that the tumor-relat-ed inflammatory response plays an important role in the prognosis of tumor. Furthermore,the tumor-related in-flammatory response can be reflected by the patient′s neutrophils,lymphocytes,monocytes and other peripheral blood indicators,such as peripheral blood lymphocytes and mononuclear cells ratio( LMR) . LMR plays an impor-tant role in the diagnosis and prognosis of tumor patients. In many studies from China and other countries,LMR has been described digestive,blood and other systems of malignant tumors,which it plays an important role in the prognosis. There is little domestic and foreign report on the research progress of LMR on the gynecological repro-ductive system. Therefore,this article reviews the effect of LMR on the prognosis of common gynecological malig-nancies.