ABSTRACT
Strain-resource engineering is often considered as an important infrastructure of microbiology related research and industry. The western developed countries took the lead in establishing the classical microbial resource utilization method, and continuously improved the preservation system, species annotation technology and global sharing mechanism, which realized the expansion and reserve of biological resources since end of the 19th century. The rich and diversified germplasm resources, standard strains and production strains not only have important economic values, but also maintain the advantages of scientific research, bioeconomy (such as antimicrobial agents, vaccines, detection reagent development and standard development, etc.) and national security. Although there has been a lot of progress in related research in recent years, compared with developed countries, there is still a big gap in related fields in China. The investment and top-level design in this area lag far behind the western developed countries, and it is not commensurate with the current level of economic and social development in my country. Drawing lessons from the practice of WFCC and WDCM (World Data Center for Microorganisms, Global microbial data Center, affiliated to WFCC), for the purpose of collecting new clinical species/strains, this paper puts forward some suggestions on the identification, preservation and upload system of isolates.
ABSTRACT
Aspirin is one of the most important non-steroidal anti-inflammatory drugs,could inhibit cyclooxygenase.It has the antipyretic-analgesic,anti-inflammatory and anti-platelet effects,and has been widely used in preventing heart cerebrovascular disease and rheumatic autoimmune disease.Neovascularization is a self-healing mechanism.However,it also plays the role of the destroyer in cancer and eye diseases at the same time.The pathology of aspirin in the generation of neovascularization,is still in the stage of a fierce debate.On one hand,aspirin has a certain inhibitory effect to the vascular endothelial growth factor (VEGF),which is the strongest factor in neovascularization.On the other hand,aspirin also has the strongest inhibitory effect to endostatin,which is a kind of anti-neovascularization factor.That may lead to the producing of VEGF.Moreover,aspirin may destroy the blood retinal barrier (BRB),which can also cause the formation of retinal neovascularization in a way.Meanwhile,we analyzed the role of aspirin in diseases which can form the neovascular.In the future study,the relationship between aspirin and neovascularization of eye will be further studied.We must measure the pros and cons in the prevention and control of neovascularization when using aspirin.
ABSTRACT
The article describes the essence,element,and contents in the new stage of the informed consent,makes discussions on how to effectively implement the principles of informed content in public health practices,and compares the similarities and differences of informed consent in public health ethics,clinical ethics,and biomedical ethics.