ABSTRACT
Objective To investigate the diagnositc value of high frequency ultrasound guided fine needle aspirates (FNA) and thyroglobulin (Tg) in fine-needle aspirate fluid (FNA-Tg) measurement for detecting metastatic lymph nodes in patients underwent thyroidectomy for papillary thyroid carcinoma (PTC).Methods Sixty-five patients with 79 suspected metastatic lymph nodes were retrospective analysis in this study.FNA for suspected lymph nodes was performed guided by high frequency ultrasound and FNATg was measured.The histopathologic diagnosis for all of the suspected lymph nodes was obtained after lymphadenectomy.Results By histopathologic diagnosis,62 lymph nodes were positive metastasis,while 17 were negative metastasis.Fifty-four lymph nodes were diagnosed as positive metastasis and 25 as negative metastasis by FNA.The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of FNA for assessing cervical metastatic lymph nodes from PTC were 89.87％ (71/79),87.10％ (54/62),100％ (17/17),100％ (54/54) and 68.00％ (17/25),respectively.Sixty-five lymph nodes were diagnosed as positive metastasis and 14 as negative metastasis by FNA-Tg.The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of FNA-Tg were 96.20％ (76/79),100％ (62/62),82.35％ (14/17),95.38％ (62/65) and 100％ (14/14),respectively.There was no significant difference between FNA and FNA-Tg for evaluating cervical metastatic lymph nodes from PTC (x2 =1.454,P =0.228).Eight positive metastatic lymph nodes which were missed by FNA were corrected diagnosed by FNA-Tg measurement.Conclusions Both FNA and FNA-Tg are effective methods for assessing cervical metastatic lymph nodes from PTC postoperatively,and these two methods could be combined for early and accurate evaluating the lymph nodes state.
ABSTRACT
Objective To explore the changes of bone mineral density and risk factors of OP in old female patients with type Ⅱ diabetes.Methods 737 cases of old female patients with type Ⅱ diabetes in Department of Endocrinology were analyzed.All patients were first divided into two groups(Group A,with OP;Group B,without OP)according to OP.Then,the changes of bone mineral density and related risk factors were analyzed with Logistic regression approach.Results In the comparison of Group A and Group B,the results are shown as follows.In Group A:ICTP(7.34±1.84)μg/L,FBG(7.12±1.14)mmol/L,BMI(22.45±2.37)kg/m2,BMD,A(62.45±17.56);InGroup B,the corresponding levels were(4.13±1.07)μg/L,(8.48±1.28)mmol/L,(15.46±6.78)mmol/L,(89.75±14.56)respectively.The resuhs presented statistical differences.(t=29.958、-14.405、16.262、-22.665,both P＜0.05).In Group A,HbAle(7.33±0.32)%,serum calcium(2.35±0.72)mmol/L,serum phosphorus(1.03±0.23)mmol/L,the corresponding values in Group B are(7.21±0.24)%,(2.42±0.34)mmol/L,(1.02±0.28)mmol/L.There sxe no statistical differences in two groups(both P＞0.05).In Group A,FN(52.50±18.40)pmol/L,UALB was(8.03 ±1.86)mg/L,Leptin was(5.14 ±1.19)μg/L;the Values in Group B were (40.70±16.34)pmol/L,(5.91±1.24)mg/L,(5.63±1.23)μg/L,The values of FN,UALB in both groups had statistical differences(t=7.469、18.515,both P＜0.05);the values of Loptin in two groups had no statistical difference(P＞0.05).Based on the incidence of OP among old female patients,the leveh of HbAlc,serum calcium,serum phosphorus,ICTP,FBG,BMI、BMD,FN,UALB,Leptin,course of disease,losing body mass,were taken as independent variables and to analyze use Logistic Regression approach.Conclusion FN,UALB,course of disease,BMI and losing body mass were the independent risk factors of OP in old female patients with type Ⅱ diabetes.