Expression of Salivary Resistin in Oral Premalignant Individuals

Introduction:Resistin, (Retn) a pro -inflammatory cytokine, accumulates at the site of inflammation.It is found to be elevated in chronic inflammation. The aim of this present study is to evaluate the levels of salivary resistin in healthy individuals and in patients with Oral pre-malignant lesion.Materials and Methods: This case control study comprises of total 90 patients which includes 45 healthy controls and 45 cases diagnosed with oral pre-malignant lesions. Salivary levels of resistin and clinical parameters were evaluated in all of them. Socio -demographic data (age, gender and residence) was collected from all participants through a questionnaire. In addition, we also recorded the total duration of tobacco usage (in years), daily frequency, and intra-oral examination and oral hygiene practices. This was followed by evaluation of clinical parameters of oral premalignant lesions and investigation of salivary levels of resistin through ELISA Results: Thesaliva of all the patients showed presence of resistin. On analyzing the samples present study shows no significant difference and variation in the salivary levels of resistin in healthy and OPML patients.Conclusion: With the results of this study, it can be concluded that there is no significant difference in the salivary levels of resistin in healthy individuals and individuals diagnosed with oral pre-malignant lesion

Association Between Grading of Oral Submucous Fibrosis With Frequency and Consumption of Areca Nut and Its Derivatives in a Wide Age Group: A Multi-centric Cross Sectional Study From Karachi, Pakistan

BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic, premalignant condition of the oral mucosa and one of the commonest potentially malignant disorders amongst the Asian population. The objective of this study was to investigate the association of etiologic factors with: age, frequency, duration of consumption of areca nut and its derivatives, and the severity of clinical manifestations. METHODS: A cross-sectional, multi centric study was conducted over 8 years on clinically diagnosed OSMF cases (n = 765) from both public and private tertiary care centers. Sample size was determined by World Health Organization sample size calculator. Consumption of areca nut in different forms, frequency of daily usage, years of chewing, degree of mouth opening and duration of the condition were recorded. Level of significance was kept at P < or = 0.05. RESULTS: A total of 765 patients of OSMF were examined, of whom 396 (51.8%) were male and 369 (48.2%) female with a mean age of 29.17 years. Mild OSMF was seen in 61 cases (8.0%), moderate OSMF in 353 (46.1%) and severe OSMF in 417 (54.5%) subjects. Areca nut and other derivatives were most frequently consumed and showed significant risk in the severity of OSMF (P < or = 0.0001). Age of the sample and duration of chewing years were also significant (P = 0.012). CONCLUSIONS: The relative risk of OSMF increased with duration and frequency of areca nut consumption especially from an early age of onset.

Cherubism: Case reports and review of the literature

Four case reports are presented of Cherubism, a rare, often inherited, bone disorder, characterized by giant cell lesional replacement of the facial bones. The lesions manifest as painless jaw swellings seen as characteristic radiolucent bilateral multilocularities arising in young children. When large and symmetric, diagnosis is clinically obvious but, with dental disruption and, in the early stages with seemingly unilateral presentations, diagnosis can be challenging. Early diagnosis is emphasized because general consensus is for the avoidance of surgical intervention where possible. Current modalities and views on the management and treatment options are reviewed

Retention and extravasation lesions of the salivary glands

A variety of disorders affect the salivary glands. Many of these are infective inflammatory, neoplastic or autoimmune in origin. A group of more common benign disorders that have salivary retention or extravasation as a common factor are the mucoceles and sialoliths. Since they are fairly common and may often be conservatively or easily managed the general dentist should be aware of these. More important, the dentist should be able to work on a process of exclusion so that more serious disorders do not get mis-diagnosed. This is a review article