ABSTRACT
Abstract The aim of this study was to perform a systematic review (SR) of the therapeutic effect of ozonated oil for oral lesions treatment. A SR was conducted according to the PRISMA guidelines. The Medline (PubMed), Embase, Cochrane Library, Scielo and LILACS were investigated, together with manual searches, to extract all publications until December 2020, including randomized and non-randomized clinical trials reporting the effects of ozonated oils on the management of oral lesions when compared with other methods. The risk of bias (RoB) of the studies included were assessed by using the RoB 2 tool and ROBINS-I. After analyzing the titles and reading the abstracts, 1932 articles were excluded; the remaining 25 passed a full-text evaluation. Ultimately, 13 articles were included in this SR. There was heterogeneity of the results regarding healing times and intervals of ozonated oil application for the treatment of each type of oral lesion, but in general, there was a shorter healing time when ozonated oil was used as therapy, and no adverse effects were reported. Despite the limited information found and the lack of rigorous methodological standards for the use of ozonated oil on oral lesions, a positive effect was suggested. The findings indicated an advantage in terms of shorter healing times when compared with other conventional treatments. No adverse effects were reported, showing safety and reliability for patient's treatment.
Resumen El objetivo de este estudio fue realizar una revisión sistemática (RS) del efecto terapéutico del aceite ozonizado sobre las lesiones orales. Se realizó una RS siguiendo las directrices PRISMA. Se realizaron búsquedas en Medline (PubMed), Embase, Cochrane Library, Scielo y LILACS, y búsquedas manuales, que abarcaron hasta diciembre de 2020, de ensayos clínicos aleatorizados y no aleatorizados que informaran sobre el efecto de los aceites ozonizados en el tratamiento de las lesiones orales en comparación con cualquier otro método. El riesgo de sesgo (RoB) de los estudios incluidos se evaluó mediante la herramienta RoB 2 y ROBINS-I. Tras analizar los títulos y leer los resúmenes, se excluyeron 1932 artículos; los 25 restantes pasaron una evaluación exhaustiva del texto completo. Finalmente, se incluyeron 13 artículos en esta RS. Hubo heterogeneidad de resultados en cuanto a los tiempos de cicatrización y los intervalos de aplicación del aceite ozonizado para el tratamiento de cada tipo de lesión oral, pero en general, hubo un menor tiempo de cicatrización cuando se utilizó el aceite ozonizado como terapia, y no se comunicaron efectos adversos. A pesar de la limitada información encontrada y de la falta de normas metodológicas rigurosas sobre el uso de aceite ozonizado en lesiones orales, se sugirió un efecto positivo del uso de aceite ozonizado para el tratamiento de lesiones orales. Los resultados indicaron una ventaja en términos de menor tiempo de curación en comparación con otros tratamientos convencionales; además, no se notificaron efectos adversos, por lo que se demostró una opción de tratamiento segura y fiable para los pacientes.
ABSTRACT
Abstract The aim of this review is to summarize the evidence on associations between diabetes mellitus (DM) and complications around dental implants. Electronic database searches of MEDLINE, EMBASE, JBI Database of Systematic Reviews and Implementation Reports, Cochrane Database of Systematic Reviews and the PROSPERO register were performed from 1990 up to and including May 2018, using MeSH terms and other keywords. Systematic reviews and meta-analyses investigating the associations of DM and implant complications (failure, survival, bone loss, peri-implant diseases, and post-surgery infection) were eligible. The quality of the included reviews was determined using the Assessment of Multiple Systematic Reviews Tool 2 (AMSTAR 2). Twelve systematic reviews were included. Implant survival rates ranged from 83.5% to 100%, while implant failure rates varied from 0% to 14.3% for subjects with DM. The three meta-analyses performed for event "implant failure" reported no statistically significant differences between diabetic and non-diabetic subjects. An apparently increased risk of peri-implantitis is reported in patients with DM. According to the AMSTAR 2 classification, 50% of the reviews were classified as being of "critically low", 25% as of "low" and 25% as of "moderate" quality. Evidence indicates high levels of survival and low levels of failure of implants inserted in patients with DM. However, DM was assessed as a whole in the majority of studies and, the actual influence of hyperglycemia on implant survival/failure is still uncertain. DM/hyperglycemia seems to be associated with a high risk of peri-implantitis. However, this conclusion is based on a limited number of systematic reviews.
Subject(s)
Humans , Diabetes Complications/complications , Peri-Implantitis/etiology , Prosthesis Failure , Dental Implants/adverse effects , Risk Factors , Treatment Failure , Dental Restoration FailureABSTRACT
Identificar las principales manifestaciones bucales en pacientes con insuficiencia renal crónica en hemodiálisis del Hospital Alberto Sabogal Sologuren (Bellavista, Callao, Perú) durante el periodo de julio-agosto 2013. Material y métodos: Se examinaron 119 pacientes de ambos sexos, realizándoseles una anamnesis y luego, con la ayuda de una linterna, espejos bucales y bajalenguas, se les examinó la cavidad bucal de manera minuciosa. Resultados: Los pacientes examinados presentaron: lengua saburral 88,2%, agrandamiento gingival 63%, sangrado gingival 55,5%, caries dental 85,7%, cálculo dental 80,7%, perdida de inserción dental 72,3%, xerostomía 84%, halitosis 66,4% y disgeusia 55,5%. Se estudió la relación de las manifestaciones bucales según el tiempo de hemodiálisis, encontrándose que existió una asociación estadísticamente significativa en la mayoría de las lesiones (prueba de Chi Cuadrado; p<0,05). Conclusión: Los pacientes con insuficiencia renal crónica en tratamiento de hemodiálisis, presentaron múltiples manifestaciones bucales propias de la enfermedad y también como consecuencia del tratamiento aplicado, donde se ven afectados los tejidos blandos, tejidos duros y glándulas salivales...
Objective: To identify the main oral manifestations in patients with chronic renal failure on hemodialysis of Alberto Sabogal Sologuren Hospital (Bellavista, Callao, Perú) during the period from July to August 2013. Methods: 119 patients of both sexes were examined performing an anamnesis and then with the help of a flashlight, mouth mirrors and tongue depressors, their buccal cavity were thoroughly examined. Results: The patients examined results were: furred tongue 88.2%, gingival enlargement 63%, gingival bleeding 55.5%, dental caries 80.7%, dental calculus 80.7%, dental insertion loss 72.3%, xerostomia 84%, halitosis 66.4% and dysgeusia 55.5%. The relationship of the oral manifestations by the time of hemodialysis was studied, finding that there was a statistically significant association in most lesions (chi square test, p <0.05). Conclusion: The patients with chronic renal failure undergoing hemodialysis showed multiple own oral manifestations of the disease and also as a result of the treatment applied, which affected soft tissues, hard tissues and salivary glands...