Factors Influencing Health-related Quality of Life among Knee or Hip Arthroplasty Patients / 기본간호학회지

PURPOSE: The purpose of this research was to identify factors that influence health-related quality of life of patients who have had knee or hip arthroplasty. Factors included sleep disorders, pain, activities of daily living, and depression. METHODS: The participants in this research were 97 patients within one year after receiving knee or hip arthroplasty surgery and who regularly visited a hospital outpatient department. Data were analyzed using descriptive statistics, t-test, ANOVA, and stepwise regression analysis with the SPSS program. RESULTS: Sleep disorders, pain, activities of daily living, and depression had significant correlations with health related quality of life. Factors influencing health-related quality of life among arthroplasty patients were the length of time since surgery, sleep disorders, activities of daily living, and depression. These factors explained 58% of the participants' health-related quality of life. CONCLUSION: The results show that various factors can affect patients' health-related quality of life following joint replacement surgery. The findings indicate that sleep disorders and depression should receive continued attention after the arthroplasty. It is also necessary to develop appropriate nursing intervention programs to lower depression and increase patient participation in daily living activities.

The Effects of P6 Acupressure and Guided Imagery on Nausea, Vomiting, Retching and Anorexia of the Patients with Thyroid Cancer Undergoing Radioactive Iodine Therapy

PURPOSE: The purpose of this study was to evaluate the effects of P6 acupressure and guided imagery on nausea, vomiting, retching, and anorexia of the patient with thyroid cancer who were undergoing high dose radio-active iodine therapy (HD-RAIT). METHODS: Using a randomized control group pretest-posttest study design, the participants were randomly assigned into the control group (C), the experimental group I (E1, P6 acupressure only) and the experimental group II (E2, P6 acupressure and a guided imagery). The patients were recruited from December 2011 to June 2012 in a tertiary hospital in Seoul, South Korea. A total of 82 patients completed the study. The Korean version of the Rhodes INVR and the anorexia scale by Grant (1987) were used. RESULTS: The levels of nausea, vomiting, retching, and anorexia were significantly different among the groups. The levels of nausea and retching especially showed significant group differences over time. Synergic effects of P6 acupressure with guided imagery had significant effects over separate P6 acupressure intervention. CONCLUSION: Non-pharmacological and nurse-provided P6 acupressure and guided imagery appeared to be effective and safe in reducing nausea, vomiting, retching, and anorexia of the patients with thyroid cancer underwent HD-RAIT.

Effect of Music Therapy as Intervention on Peripheral Neuropathic Pain and Anxiety of Gynecologic Cancer Patients Undergoing Paclitaxel Chemotherapy / 여성건강간호학회지

PURPOSE: This study was to investigate the effect of music therapy as intervention on peripheral neuropathic pain and anxiety of gynecologic cancer patients who were undergoing paclitaxel chemotherapy. METHODS: Hospitalized 62 patients were assigned to an experimental group (n=30) and a control group (n=33) in this quasi-experimental study. The experimental group participated in music therapy that includes listening, singing and song writing during 1 hour. The peripheral neuropathic pain, anxiety and depression were examined as pre-intervention evaluation by using pain scale, anxiety scale (20 questions) and depression scale (20 questions) in both groups. There were no further treatments for the control group while the experimental group involved in music therapy. The peripheral neuropathic pain and anxiety were evaluated in both groups as post-intervention evaluation. RESULTS: Outcomes were verified through hypothesis testing. The level of peripheral neuropathic pain and anxiety in the experimental group was decreased, compared to the control group. CONCLUSION: According to the study, music therapy is a beneficial intervention that reduces peripheral neuropathic pain and anxiety in gynecologic cancer patients. These findings are encouraging and suggest that music therapy can be applied as an effective intervention for minimizing chemotherapy related symptoms.

A Public-Private Collaboration Model for Treatment Intervention to Improve Outcomes in Patients with Tuberculosis in the Private Sector / 결핵및호흡기질환

BACKGROUND: The treatment success rates in patients with tuberculosis are known to be lower in the private sector compared to the public sector. To improve treatment outcomes in the private sector we developed a public-private collaboration model for strengthening health education and case holding activities with public health nursing in the private sector. METHODS: We performed a prospective cohort study in new smear positive pulmonary tuberculosis patients treated at private hospitals, selected by non-randomization, with an intervention consisting of health education and case holding activities by specially trained public health nurses (intervention group) results were compared with cases treated without the intervention (conventional group). Physicians were asked to treat both groups routinely. The treatment outcomes of patients under treatment by the National Tuberculosis Programme were also analyzed for comparison. RESULTS: There were 172 cases each in the intervention and conventional groups. The mean age was 48.9+/-19.0 and 48.2+/-19.7 in the respective groups (p=0.66). The PHN interacted with the cases in the intervention group by initial face to face interview and telephone calls an average of 7.1+/-9.2 times during the initial six months. The intervention group showed a significantly higher treatment success rate, 91.6%, (Rate Ratio [RR]; 1.23, 95% Confidence Interval [CI]; 1.12~1.36), lower default, 3.6%, (RR; 0.31, 95% CI; 0.13~0.75) and transfer-out rate, 3.0%, (RR; 0.32, 95% CI; 0.12~0.86) than the conventional group where they were: 75.0%, 11.6%, 9.3%, respectively. The success rate was even higher than the rate (80.5%) of 1,027 cases treated in health centers (RR; 1.11, 95% CI; 1.05~1.17). Of the completed cases in the intervention group, 82.2% regarded the role of the public health nurse as very helpful. CONCLUSION: The treatment success rate, of tuberculosis patients in the private sector, was significantly improved by an intervention using a public-private collaboration model.

Knowledge and Attitudes toward Tuberculosis among High School Students in Busan / 결핵및호흡기질환

BACKGROUND: The mortality rate from tuberculosis in Korea is the highest among OECD countries. However, general public's knowledge of tuberculosis is limited. Currently, exposure to tuberculosis in high school students is a big problem. METHODS: A written questionnaire was distributed to 78 high school students in Busan. RESULTS: Almost all the students had heard of tuberculosis (95%). However, their knowledge of tuberculosis was very superficial and limited. The attitude about tuberculosis was 'nothing to worry about' and there was no systemic education in the school or home. CONCLUSION: Although tuberculosis is quite serious in Korea, most people know little about it and have the wrong attitude. In particular, high school students are easily exposed to tuberculosis because they spend most of their time as a group. Therefore, education of high school students on tuberculosis is strongly recommended in schools and the home. In addition, medical practitioners should play a role in education and prevention programs.

Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the major pungent ingredient of red pepper, has been reported to possess anti-carcinogenic and anti-mutagenic activities. In this study, the anti-migration activity of capsaicin on highly metastatic B16-F10 melanoma cells was investigated. Capsaicin significantly inhibited the migration of melanoma cells without showing obvious cellular cytotoxicity at low doses. This effect correlated with the down-regulation of phosphatidylinositol 3-kinase (PI3-K) and its downstream target, Akt. Although B16-F10 cell migration was increased by the PI3-K activator through the activation of Akt, these PI3-K activator-induced phenomena were attenuated by capsaicin. Moreover, capsaicin was found to significantly inhibit Rac1 activity in a pull-down assay. These results demonstrate that capsaicin inhibits the migration of B16-F10 cells through the inhibition of the PI3-K/Akt/Rac1 signal pathway. The present investigation suggests that capsaicin targets PI3-K/Akt/ Rac1-mediated cellular events in B16-F10 melanoma cells. Consequently, capsaicin administration should be considered an effective approach for the suppression of invasion and metastasis in malignant melanoma chemotherapy.

Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes

The present study was undertaken to explore whether retinoids, which are known to have immunomodulatory actions, could attenuate tumor necrosis factor-alpha (TNF)-stimulated inducible nitric oxide synthase (iNOS) expression in 3T3-L1 adipocytes. Adipocytes incubated with TNF induced dose- and time-dependent accumulation of nitrite in the culture medium through the iNOS induction as confirmed by Western blotting. Treatment of cells with TNF in the presence of all-trans-retinoic acid (RA) significantly decreased their ability to produce nitrite and iNOS induction. Both 13-cis- and all- trans-RA-induced suppression was dose-dependent, and all-trans-RA was somewhat potent than 13-cis-RA. The inhibitory effect of RA on TNF-induced iNOS induction was reversible, completely recovered after 2 days, and was exerted through the inhibition of NF-kappaB activation. TNF also suppressed the lipoprotein lipase (LPL) activity of 3T3-L1 adipocytes. RA could not reverse the TNF- induced LPL suppression at RA levels causing near complete inhibition of the TNF-induced NO production. These results indicate that RAs attenuate iNOS expression reversibly in TNF-stimulated 3T3-L1 adipocytes, and that the TNF- induced LPL suppression is not the result of NO overproduction.

Changes of Cerebral Blood Flow Velocity in Different End Tidal Carbon Dioxide Tension during Enflurane-N2O-O2 Anesthesia / 대한마취과학회지

The changes of cerebral blood flow velocity, pulsatility index and resistance index were studied during Enflurane-N2O-O2 anesthesia according to the change of end tidal carbon dioxide tension in 14 gynecologic surgical patients. From the both middle cerebral artery, mean blood flow velocity, resistance index and pulsatility index were checked with transcranial doppler before anesthesia with room air respiration and during anesthesia with controlled ventilation. The anesthesia was controlled with 2.0+/-0.5% Enflurane and 3 liter/min. of nitrous oxide and 2 liter/min. of oxygen. The end tidal CO2 tension was controlled by change of respiratory rate and tidal volume from 30 mmHg to 40 mmHg during anesthesia. Mean blood flow velocity, resistance index, and pulsatility index of middle cerebral artery were compared between unanesthetized room air respirated patient and anesthetized patient. The result were as follows : 1. There were no differences of systolic, diastolic, mean blood flow velocity, resistance index and pulsatility index between right and left middle cerebral artery. 2. The mean blood flow velocity was significantly increased but the pulsatility index and resistance index was decreased during anesthesia compare to preanesthetic values. This may be due to the effect of anesthetics. 3. During steady state of anesthesia the mean blood flow velacity was increased and the pulsatility index and resistance index was decreased according to the change of ETCO2 With this result we can say the effect of carbon dioxide tension to the cerebral blood flow velocity was maintained during Enflurane-N2O-O2 anesthesia, but the flow was also affected by the anesthetics itself.

Anamnestic skin reactivity upon repeated tuberculin tests in the BCG vaccinated or unvaccinated primary school children / 결핵

No abstract available.