ABSTRACT
OBJECTIVE: To investigate the influence of occupational and environmental factors on the pregnancy for Down's syndrome. METHODS: By systematic sampling method,97 pregnant women who had been diagnosed as Down's syndrome by Giemsa staining on fetal chromosomes in chorionic villus sampling,amniocentesis,or umbilical cord blood sampling were selected as the case group,while 373 non-Down's syndrome pregnant women after same examinations during the same period in the same hospital were selected as the control group. The history of exposure before pregnancy to occupational and environmental factors was analyzed. RESULTS: The pregnant women aged over 35 years had higher risk of Down's syndrome than those aged under 35 years( P < 0. 01). The pregnant women with occupational exposure to organic solvents containing benzene had higher risk of Down's syndrome than those without occupational exposure history to hazardous substances( P < 0. 01). The pregnant women using estrogenic drugs before pregnancy or during early pregnancy had higher risk of Down's syndrome than those without drug use( P < 0. 05). The pregnant women living in newly-decorated houses or using the new furniture had higher risk of Down's syndrome than those without new decoration( P < 0. 01). The pregnant women with pre-pregnancy intake of folic acid had lower risk of Down's syndrome than those without any intake of folic acid supplement( P < 0. 05). CONCLUSION: The age,occupational exposure to benzene solvents and taking estrogenic drugs were the major leading factors of development of Down's syndrome.
ABSTRACT
OBJECTIVE: To analyze the current prevalence status of gynecological diseases on female workers in an automobile manufacturing company. METHODS: By judgment sampling,382 female workers who exposed to occupational hazard factors were selected as exposure group and 367 female executive staffs without exposure to those factors were selected as control group. Among the three subgroups of the exposure group,the prevalence rate of vaginitis,pelvic inflammatory disease,cervicitis,annex cysts,ovarian cysts and uterine fibroid in these two groups were analyzed. RESULTS: The prevalence rate of vaginitis and uterine fibroid in exposure group was higher than that of control group(24. 9% vs20. 7%,20. 4% vs 9. 8%,P < 0. 05). Among the three subgroups of the exposure group,the prevalence rate of vaginitis in welding subgroup was the highest(35. 4%,P < 0. 017); the prevalence rate of annex cysts in coating subgroup was the highest among all subgroups(11. 4%,P < 0. 017); the prevalence rate of uterine fibroid in assembly subgroup was the highest(28. 1%,P < 0. 017). The prevalence rate of uterine fibroid in exposure group presented an increasing tendency with the increase of age(P < 0. 05). The prevalence rate of cervicitis,annex cysts and uterine fibroid in exposure group presented an increasing tendency with the increase of seniority(P < 0. 05). CONCLUSION: The prevalence rate of gynecological diseases in female workers who exposed to occupational hazard factors in an automobile manufacturing company was significantly higher than general population. The prevalence rate of gynecological diseases among different types of female workers was significantly different. Disparity of gynecological diseases prevalence of female workers might due to differences in occupational hazard factors exposure.