ABSTRACT
The aim of this study was to Investigate the relationship between metabolic risk factors and oxidative stress using urinary 8-hydroxydeoxyguanosine [8-OHdG], a recently utilized biological marker, in asymptomatic subjects. Ninety subjects [males/females = 30/60; mean age = 52 years], who were nonsmoking, nondiabetic and not on any medicine, were enrolled in the study. The body mass index, blood pressure, total cholesterol, triglyceride [TG], high-density lipoprotein cholesterol [HDL-C] and glucose as well as urinary 8-OHdG and creatinine were measured. The median level of 8-OHdG was 9.3 ng/mg creatinine [nterquartile range: 5.8-23.2]. TG [Pearson's correlation: r = 0.262, p - 0.013] and HDL-C [r - -0.259, p - 0.014] showed a significant correlation with 8-OHdG. A multiple linear regression analysis adjusted for all the variables revealed that only TG had an independently significant and positive correlation with 8-OHdG [p = 0.231, p = 0.046]. The data in this population suggest that, among metabolic risk factors, hypertriglyceridemia may be weakly but significantly associated with hyperoxidative stress as assessed by 8-OHdG
ABSTRACT
It was the aim of this study to investigate whether there is any relationship between oxidative stress, as assessed by the diacron reactive oxygen metabolite [d-ROM] test, and carotid atherosclerosis among hypercholesterolemic patients. A well-defined group of patients with type II hypercholesterolemia [n = 81, mean age 59 years] was studied to observe the correlation between the levels of serum d-ROMs and carotid artery intima-media thickness [IMT] using B-mode ultrasound, in relation to the traditional atherosclerotic risk factors [age, sex, smoking, body mass index, blood pressure, glucose and lipid panels]. The mean level in low-density lipoprotein cholesterol [LDL-C] in this population was 4.45 mmol/l, d-ROMs were 323.2 Carr U, and IMT was 0.91 mm. A multiple regression analysis revealed a positive and significant correlation between IMT and d-ROMs [beta = 0.27, p < 0.05], along with age and LDL-C. These results indicate that the increased oxidative stress levels using the d-ROM test, independent of aging and increased LDL-C levels, may be associated with carotid atherosclerosis even in hypercholesterolemic patients
ABSTRACT
To assess the influence of smoking on glycated albumin [GA] to hemoglobin A1c [HbA1c] ratio among type 1 diabetes mellitus [T1DM] patients. Eighty-one T1DM patients [49 females, 32 males, mean age 48 +/- 18 years] were recruited, and data concerning GA/HbA1c ratio and smoking were collected. The median levels of GA and HbA1c were 23.3 and 7.4%, respectively. Independent of age, sex and/or body mass index, the GA/HbA1c ratio in smokers was significantly lower than that in nonsmokers [3.0 vs. 3.3, p < 0.05]. The data suggest that smoking might affect the GA/HbA1c ratio among T1DM patients