ABSTRACT
The aim of this work was to assess the diagnostic yield of serum tumoral markers, Ca 19-9 and carcinoembryonic antigen, in patients with gallbladder cancer. We studied 54 patients of whom 33 had gallbladder cancer and in 21 the tumor was removed previously and were presently free of disease. Twenty one patients with cholelithiasis were used as controls. Ca 19-9 was over 37 U/ml in 22 (65 percent) patients with cancer, in two patients free of disease and two controls. The sensitivity and specificity of Ca 19-9 was 0.66 and 0.90 respectively. Carcinoembryonic antigen was over 2.5 ng/ml in 25 patients with cancer (56 percent) and in sensitivity and specificity was 0.75 and 0.71 respectively. Using a cutoff point of 4 ng/ml, these figures were 0.51 and 0.9 respectively. The better predictive capacity was given by Ca 19-9 over 37 U/ml or a carcinoembryonic antigen over 4 ng/ml. It is concluded that, although the sensitivity and specificity of these markers was adequate in this work, one must hear in mind that studied patients had advanced tumors
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Gallbladder Neoplasms/immunology , /isolation & purification , Case-Control Studies , Sensitivity and Specificity , False Negative Reactions , Carcinoembryonic Antigen/isolation & purification , Biomarkers, Tumor/isolation & purificationABSTRACT
Con la finalidad de conocer la utilidad clínica de la detección de anticuerpos específicos al Echinoccus granolusos de tipo inmunoglobulinas (Ig) G y E, se estudiaron 48 pacientes portadores de hidatidosis y 110 controles. Se realizó Enzima Inmuno Ensayo (ELISA) indirecto homogéneo para Ig-G y ELISA reversa para Ig-E. Se encontró una sensibilidad de 81 por ciento para IgG y de 62,5 por ciento para IgE, con una especificidad para Ig-G de 89 por ciento y para Ig-E de 96 por ciento . Los hallazgos evidencian la utilidad clínica de la detección de ambos anticuerpos específicos para el diagnóstico de la hidatidosis humana; Ig-G como primera aproximación diagnóstica y pàra estudios seroepidemiológicos e Ig-E en primoinfección, recidiva y reinfección postcirugía