ABSTRACT
Type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic patients. Purpose of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type 2 diabetic patients. In this study 31 type 2 diabetic patients with Fasting blood Sugar [FBS]:140-200 mg/dl, Triglyceride [TG]: 200-400 mg/dl, Cholesterol [TC]: 200-300 mg/dl and mild hypertension were selected. Subjects received vitamin E 800 IU/day for 3 months. At the baseline and end of the study FBS, TC, TG, LDL, HDL, Glycated hemoglobin and fasting insulin level were measured. In this study 31 type 2 diabetic patients [19 female, 12 male] with mean age 53.03 +/- 8.87 years were studied. Vitamin E supplementation for 3 months had no positive effect on type 2 diabetic patients. As FBS, TG and fasting insulin decreased but this decline was not significant. Also total Cholesterol, systolic and diastolic blood pressure changes were not remarkable. Results of this study showed that 800 IU vitamin E administration for 3 months could not improve blood glucose, lipids, HbA1c, fasting insulin, systolic and diastolic BP in type 2 diabetic patients