ABSTRACT
Considering the fact that liver is one of the most important organs in our body, it deserves special attention and protection. Among various recommended supplements, complementary and alternative medicines particularly herbal remedies have received much attention owing to their truly healing properties. This review profits from Iranian traditional medicine and presents advantageous herbal guide directions for liver protection. According to credible Iranian medical literature such as Al Qanun Fil Tibb, Al-Havi and Makhzan-al-Aadvia, a wide spectrum of plants have been found to be useful for cleansing and protecting the liver. Some herbs such as ghafes (Agrimonia eupatoria), kasni (Cichorium intybus), anar (Punica granatum), darchin (Cinnamomum zeylanicum), za'feran (Crocus sativus), gole-sorkh (Rosa damascena) and zereshk (Berberis vulgaris) appeared to get strong consideration and were well documented as outstanding liver tonics. We conducted a comprehensive review of available Iranian medical resources such as scientific information database and medical sciences databases which cover all in vitro and in vivo studies of medicinal plants as liver tonics and hepatoprotective candidates. Literature survey was accomplished using multiple databases including PubMed, ISI web of knowledge, and Google Scholar.
ABSTRACT
New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of the obtained compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mentioned compounds were screened for their antimicrobial and antioxidant activities. Their antimicrobial activity was assigned using the conventional agar dilution method and the antioxidant activity was assessed using two methods, 1,1-diphenyl-2-picrylhydrazyl [DPPH] radical scavenging method and ferric reducing antioxidant power [FRAP] assay. Although the compounds showed no remarkable antimicrobial activities, most of them exhibited good antioxidant activities. Compounds 5b showed the most potent DPPH activity, whereas 8c was the most efficient compound in FRAP assay