ABSTRACT
Objective To study and analyze the related factors of neonatal dopamine leakage in NICU and psychological intervention. Methods 100 cases of neonatal NICU patients who received intravenous infusion of dopamine in our hospital from February 2015 to October 2017 were selected and randomly divided into two groups,the control group and the experimental group,with 10 patients in each group.The patients in the control group were given routine nursing care,the patients in the experimental group were given comprehensive care and psychological intervention,and they paid attention to the psychological status of the patients,and carried out a comprehensive evaluation,and given positive care.The clinical indexes of the experimental group and the control group were compared and analyzed. Results After the corresponding nursing mode,10 cases in the control group were transfused 100 times,and 30 cases of secondary leakage occurred,accounting for 30.0%.In the experimental group,10 cases were transfused 100 times,and 16 cases of secondary leakage occurred,accounting for 16.0%.The probability of dopamine leakage in the control group was significantly higher than that in the experimental group,with statistical difference.In the experimental group,9 parents were satisfied with the nursing work,and the satisfaction rate was 90.0%.In contrast,42 parents were satisfied with the nursing work,and the satisfaction rate was 80.0%. The satisfaction degree of nursing in the experimental group was significantly higher than that in the control group,and the difference was statistically significant.Conclusion The application of psychological intervention in neonatal NICU intravenous infusion of dopamine and comprehensive care,can reduce the occurrence probability of leakage of dopamine in a large extent,improve nursing satisfaction,to build a harmonious doctor-patient relationship is further applied in clinical significance.
ABSTRACT
Objective To investigate whether the genetic variant rs10830963 of melatonin receptor 1B(MTNR1B)gene is associated with increased risk for gestational diabetes mellitus (GDM).Methods Eighty-seven GDM subjects(GDM group)and 91 normal pregnant women (control group)were randomly recruited form Women and Children's Hospital of Quzhou,Zhejiang Province,China.The allele and genotype frequencies of the rsi0830963 in MTNR1B gene were determined in all participants with PCR amplification and DNA sequencing.The allele and genotype frequencies of rs10830963 were compared to determine their differences between GDM subjects and normal controls.In addition,multiple linear regression was conducted to investigate the association patterns of the risk allele with fasting glucose and HbAlc levels.Results Both GG genotype and G allele frequencies of the rs10830963 loci in the GDM group were significantly higher than those in the controls,and women with G allele and GG genotype were associated with increased GDM risk(OR=1.53,95％ CI:1.005-2.324,P=0.047 and OR=2.16,95％ CI:1.052-4.434,P=0.034 respectively).After adjusting for age,body mass index before pregnancy,and family history of diabetes mellitus,women carrying GG genotype still had a higher GDM risk(OR =2.07,95％ CI:1.048-4.372,P =0.022).Multiple linear regression showed that the rs10830963 G allele was positively correlated with higher levels of fasting glucose(0.068 mmol/L,P=0.015)and HbAlc(0.073％,P=0.028).Conclusions Genetic variant rs10830963 in MTNR1B gene may contribute to the susceptibility to GDM in Chinese population and the rs10830963 G allele is a risk factor for the GDM susceptibility.