CADY-based cell penetrating peptides as siRNA delivery vector:research progress / 国际药学研究杂志

How to deliver small interfering RNA(siRNA)molecules into target cells efficiently and safely to silence target genes is a bottleneck in the clinical application of RNA interference. In recent years,siRNA delivery technology based on cell pene-trating peptides has developed rapidly. Among them,the secondary amphipathic peptide,called CADY,has little cytotoxicity and no immunogenicity,forms stable siRNA complexes and improves their delivery into a wide variety of cell lines. Therefore,it has become a very promising delivery carrier for siRNA applications. This review summarizes the design idea,structural characteristic,spatial con-figuration,internalization mechanism,modification and application of CADY.