ABSTRACT
Alzheimer's disease (AD) is a central nervous system disorder with memory and cognitive decline as the main clinical manifestation. Some progresses have been made in laboratory research and clinical applications of the traditional Chinese medicine for AD treatment. However, the AD pathology mechanism and the target of the traditional Chinese medicine remain unclear yet. Bloodbrain barrier (BBB) plays a critical role to maintain the dynamic balance of the central nervous system. In the pathological process of AD, the BBB impairment and the abnormity of transporters expression have certain effects on the clearance of amyloid beta-peptides and the drug transport across BBB. This review summarizes the research progress on the traditional Chinese medicine treatment of AD and the dysfunction of BBB transporters, thus providing new prevention and treatment strategies for AD.