ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Aidi Injection (艾迪注射液,ADI) applied in the bronchial artery, applied in the bronchial artery infused (BAI) neo-adjuvant chemotherapy for stage III A non-small cell lung cancer (NSCLC) before surgical operation.</p><p><b>METHODS</b>The 60 patients with NSCLC stage III A underwent two courses BAI chemotherapy before tumor incision were assigned to two groups, the treatment and the control groups, using a random number table, 30 in each group. ADI (100 mL) was given to the patients in the treatment group by adding into 500 mL of 5% glucose injection for intravenous dripping once daily, starting from 3 days before each course of chemotherapy, and it lasted for 14 successive days, so a total of 28 days of administration was completed. The therapeutic effectiveness and the adverse reaction that occurred were observed, and the levels of T-lymphocyte subsets, natural killer cell activity, and interleukin-2 in peripheral blood were measured before and after the treatment.</p><p><b>RESULTS</b>The effective rate in the treatment group was higher than that in the control group (70.0% vs. 56.7%, P<0.05). Moreover, as compared with the control group, the adverse reaction that occurred in the treatment group was less and mild, especially in terms of bone marrow suppression and liver function damage (P<0.05). Cellular immune function was suppressed in NSCLC patients, but after treatment, it ameliorated significantly in the treatment group, showing significant difference as compared with that in the control group (P<0.05).</p><p><b>CONCLUSION</b>ADI was an ideal auxiliary drug for the patients in stage III A NSCLC received BAI neo-chemotherapy before surgical operation; it could enhance the effectiveness of chemotherapy, ameliorate the adverse reaction and elevate patients' cellular immune function; therefore, it is worthy for spreading in clinical practice.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Antineoplastic Agents , Pharmacology , Therapeutic Uses , Bronchial Arteries , Pathology , Carcinoma, Non-Small-Cell Lung , Blood , Drug Therapy , Allergy and Immunology , General Surgery , Chemotherapy, Adjuvant , Drugs, Chinese Herbal , Pharmacology , Therapeutic Uses , Infusions, Intra-Arterial , Injections , Interleukin-2 , Blood , Killer Cells, Natural , Allergy and Immunology , Lung Neoplasms , Blood , Drug Therapy , Allergy and Immunology , General Surgery , Lymphocyte Subsets , Allergy and Immunology , Neoplasm Staging , Time Factors , Treatment OutcomeABSTRACT
The effect of osmotic pressure on nitrification was investigated in the internal-loop air-lift nitrifying reactor. When influent ammonia concentration is kept at 420mg x L(-1) and influent osmotic pressure is increased from 4.3 to 18.8 x 10(5) Pa, the ammonia conversion of the nitrifying bioreactor is maintained between 93% and 100%. After influent osmotic pressure is further increased to 19.2 x 10(5)Pa, the ammonia conversion goes down to 69.2%. The influence of osmotic pressure on nitrification takes place without any alarm and the critical osmotic pressure is between 18.8 x 10(5) and 19.2 x 10(5) Pa. During osmotic stress, the nitrifying bacterial populations in the activated sludge become simplified, the cell size becomes smaller, the inner membrane becomes less and some unknown inclusion particles are formed. The cell structure is restored as soon as the osmotic pressure is removed. Addition of potassium is able to relieve the effect of osmotic pressure on nitrification. The nitrifying activity of the activated sludge is stimulated by the osmotic stress, and the specific ammonia conversion is increased from 0.083 kg x kg(-1) x d(-1) to 0.509 kg x kg(-1) x d(-1) and 2.569 kg x kg(-1) x d(-1), respectively.