1.
Acta Pharmaceutica Sinica
;
(12): 1017-1025, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-780179
ABSTRACT
The drug delivery system with "gatekeeper" is designed to achieve a stable entrapment state of the payload under normal physiological conditions through the gatekeepers. With tumor microenvironment or stimulation of exogenous factors, the gatekeeper is detached or altered to promote the responsive release of the drug. In this paper, we focus on applications of stimuli-responsive linkages and stimuli-responsive groups, and review research progresses of drug delivery system with "gatekeeper" developed over the past 10 years.