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Objective@#To investigate the prevalence of dyslipidemia among adults in Moyu County, Hotan Prefecture, Xinjiang Uygur Autonomous Region, so as to provide insights into the management of dyslipidemia.@*Methods@#The physical examination data of permanent residents at ages of 18 years and older were collected from Moyu County from 2018 to 2019, including demographic features, height, body weight, blood pressure and blood biochemical parameter measurements. The epidemiological characteristics of dyslipidemia were analyzed among residents.@*Results@#Totally 166 142 adults were investigated, with a mean age of (41.08±15.72) years. There were 77 744 men (46.76%), 34 728 obese adults (20.90%), 5 776 adults with diabetes (3.48%) and 26 294 adults with hypertension (15.83%). The levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were (1.38±0.98), (4.13±1.19), (1.31±0.41) and (2.25±0.77) mmol/L, respectively. The prevalence of dyslipidemia was 29.72%, and the detection rates of high TG, high TC, low-HDL-C and high LDL-C were 9.73%, 4.59%, 19.65% and 1.99%, respectively. The prevalence of dyslipidemia was higher in men than in women (33.97% vs. 25.98%; χ2=1 264.729, P<0.001), and the prevalence increased with age (χ2=539.382, P<0.001) and body mass index (χ2=3 601.833, P<0.001). The prevalence of dyslipidemia was 35.48% among patients with hypertension (χ2=497.251, P<0.001) and 46.07% among patients with diabetes (χ2=766.142, P<0.001). There were 9 059 adults with two and more abnormal blood lipid indexes (18.35%), and the detection rates of two and more abnormal blood lipid indexes were 26.50%, 24.14% and 33.15% among patients with obesity, hypertension and diabetes, respectively.@*Conclusions@#The prevalence of dyslipidemia among adults in Moyu County is lower than the national level, and low-HDL cholesterolemia is the most common type of dyslipidemia. The prevalence of dyslipidemia is high among patients with obesity, hypertension and diabetes mellitus, in whom abnormality of multiple blood lipid indexes is measured.
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Objective To explore the prevalence and characteristic of Non-alcoholic fatty liver disease (NAFLD) among the ethnic Kirghiz adult in Xinjiang Province. Methods The study was conducted based on the national health checkup in Xinjiang province during 2018. A total of 19 843 participants of Kirghiz adults in Aheqi County, Xinjiang Uygor Autonomous Region were selected for physical examination, questionnaires, blood biochemical indicators detection (FBG, TG, LDL-C, HDL-C, TC, ALT and AST) and abdominal ultrasonography. A total of 1 396 patients diagnosed with NAFLD by abdominal ultrasonography were selected as the case group, and 4 188 non-NAFLD subjects matched in age, sex and region were selected as the control group at a ratio of 1:3. The clinical characters and risk factors of NAFLD patients were analyzed. Results The overall prevalence of NALFD in Kirghiz adults was 7.0%, 7.8% in male, and 6.2% in female (standardized to 6.8%, 7.5%, and 6.0%, respectively). The prevalence in male was higher than that in female (P<0.01). The prevalence of NAFLD in the obesity, diabetes, and hypertension group was significantly increased, which was 19.0%, 20.6% and 18.5%, respectively. Body mass index (BMI), waist circumference (WC), triglycerides, AST (aspartate aminotransferase) and ALT (alanine transamilase) in the NAFLD group were all higher than those in the control group (all P < 0.01). In the NAFLD group, 17.2% had another one metabolic disorder and 62.0% had another two metabolic disorders. Logistic regression analysis showed that waist circumference (OR = 4.08, 95%CI = 3.04~5.10), FBG (OR = 3.76, 95%CI = 2.86~4.93) and BMI (OR = 3.32, 95%CI = 2.16~4.38) were the main independent risk factors for NAFLD. Literacy (OR = 0.42, 95%CI = 0.24~0.69) and physical activity (OR = 0.68, 95%CI = 0.45~0.96) were protective factors. Conclusion The prevalence of NAFLD in Kirgiz adults in Xinjiang is lower than the national average. More than half of NAFLD patients are comorbidity with at least two metabolic abnormalities. WC, FBG and BMI were the independent risk factors for NAFLD, however, literacy and physical activity were protective factors.
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Objective This paper analyzed the conclusion report of physical examinations by the chief inspection physician from the Health Management Center,The First Teaching Hospital of Xinjiang Medical University in Urumqi,to examine the quality of these reports.The research aimed to provide a reference for improving the quality of the chief physician's conclusions from physical examinations.Method Using the method of blinding,three senior physicians as quality control doctors analyzed the value of concordance of 12 489 conclusions from physical examinations by seven chief inspection physicians made from September to October 2017 based on three aspects,including standardization of classified disease-diagnosis handwriting,conclusions of physical examination and sequence of positive results,and unified diagnosis.Results The results showed that value of concordance of standardization of classified disease-diagnosis handwriting of the reports by the seven chief inspection physicians was 95.2％-96.5％ and of conclusions of physical examination and sequence of positive results was 94.0％-96.1％.Additionally,these two values indicated no statistically significant differences among the seven chief inspection physician (x2=9.906,9.740respectively,P＞0.05).However,the concordance value of unified diagnosis by the seven chief inspection physicians was 86.2％-94.6％,displaying statistically significant differences among the chief inspection physicians (x2=92.990,P＜0.001).Conclusion It was concluded through the research that differences in the chief inspection physicians' reports of physical examination reached normalization and unification in aspects of standardization of classified disease-diagnosis handwriting,and conclusions of physical examination and sequence of positive results.However,statistical variations in aspects of unified diagnosis revealed that training should be conducted for the chief inspection physician for physical examination.
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<p><b>OBJECTIVE</b>To test the feasibility of using 1,5-anhydroglucose alcohol (1,5-AG) as a diagnostic indicator of fulminant type 1 diabetes (FT1DM).</p><p><b>METHODS</b>Fifteen patients with newly diagnosed FT1DM and 52 with type 2 diabetes (T2DM) were examined for serum biochemistry, glycosylated hemoglobin (HbAlc), and serum 1, 5-AG level.</p><p><b>RESULTS</b>The patients with FT1DM and T2DM showed significantly different fasting levels of blood glucose (FBG), fructosamine (FMN), creatinine (Cr), urea, HbAlc and serum 1,5-AG (P<0.05). In FT1DM patients, serum 1,5-AG was found to inversely correlate with FBG (r=-0.646, P=0.032) and FMN (r=-0.680, P=0.021), and in T2DM patients, serum 1,5-AG was inversely correlated with FBG (r=-0.407, P=0.001), FMN (r=-0.314, P=0.01) and HbAlc (r=-0.576, P<0.01). Receiver-operating characteristic (ROC) curve analysis showed an area under the curve of serum 1,5-AG of 0.804 with a cutoff value of 67.95, a sensitivity of 82.9% and a specificity of 60% for FT1DM diagnosis.</p><p><b>CONCLUSION</b>Serum 1, 5-AG can reflect acute blood glucose fluctuation in FT1DM patients and is useful for differential diagnosis of FT1DM when combined with evaluations of the clinical characteristics of the patients and other related indicators.</p>
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Humans , Blood Glucose , Diabetes Mellitus, Type 1 , Blood , Diagnosis , Diabetes Mellitus, Type 2 , Blood , Diagnosis , Diagnosis, Differential , Ethanol , Glycated Hemoglobin , Chemistry , ROC Curve , Sensitivity and SpecificityABSTRACT
Objective To evaluate the relationship between iodine intake and the prevalence of thyroid diseases in Urumqi.Methods A total of 1693 subjects were investigated.Serum thyroid hormones,thyroid autoantibodies,and urinary iodine concentration were determined,and type B ultrasonography of thyroid gland was performed in all participants.Result The urinary iodine level revealed that 9.5％ of the subjects were iodine deficient and 30.0％ iodine excessive.The average median urinary iodine was 254.9 μg/L.Serum total T4 level in the idione adequate and more than adequate groups was significantly higher than the other 2 groups [ ( 9.02±2.63 ) vs (7.69±2.85)、(8.45 ±2.13 ) μg/dl,both P＜0.05 ],and serum TSH level in the idione deficient group was significantly higher than the other 2 groups [ (3.00±1.86) vs (2.37±1.91),(2.27±1.86) mIU/L,both P＜0.01 ].There was no significant statistical difference in positive rates of thyroid autoantibodies,morbidities of thyroid dysfunction and goiter among 3 groups.Conclusion The iodine deficient situation has been corrected in Urumqi.There is no difference in morbidities of thyroid diseases in population with different iodine intakes.