Expression of human telomerase reverse transcriptase and proliferating cell nuclear antigen in pleural and peritoneal effusion / 第三军医大学学报

Objective To explore the diagnostic value of human telomerase reverse transcriptase (hTERT) and proliferating cell nuclear antigen (PCNA) in pleural and peritoneal effusion. Methods The expressions of hTERT and PCNA were detected by immunocytochemistry in 46 malignant and 21 benign serous specimens. Results hTERT and PCNA were detected respectively in 39 and 29 of 46 malignant specimens, but no expressions in reactive mesothelial cells in all serous specimens. hTERT correlated with PCNA (r=0.30, P