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OBJECTIVE@#To investigate the pre-pregnancy body mass index(BMI), gestational weight gain(GWG)and gestational outcomes in women with high normotension during pregnancy.@*METHODS@#The clinical data of 1500 pregnant women who recieved antenatal care and delivered in Songjiang District Maternal and Child Hospital, Shanghai from 2015 to 2017 were retrospectively analyzed. The women were divided into high normotension group, normotension group and hypertensive disorder of pregnancy (HDP) group with 500 cases in each group. The general information, pre-pregnancy body mass index, gestational weight gain and gestational outcomes were analyzed.@*RESULTS@#There were significant differences in pre-pregnancy BMI and GWG between the high normotension group and the normotension group (all 0.017); the incidence of oligohydramnios, placental abruption, cesarean section, postpartum hemorrhage, premature delivery and small for gestational age infant in HDP group were higher than those in high normotension group (all <0.01). In high normotension women with adverse gestational outcomes, the proportion of low GWG or too much GWG was higher and the proportion of normal GWG was lower than those in high normotension women without adverse gestational outcomes (all <0.01).@*CONCLUSIONS@#Pre-pregnancy BMI and GWG are correlated with pregnancy blood pressure and gestational outcomes. Reasonable intervention to gestational weight gain of pregnant women with high normotension is of significance to improve the gestational outcomes.
Subject(s)
Child , Female , Humans , Pregnancy , Blood Pressure , Body Weight , Cesarean Section , China , Pregnancy Outcome , Retrospective StudiesABSTRACT
Teaching method is important to carry through the content of the course and guarantee the teaching quality.We have proceeded some reforms and research in the Obstetrics and Gynecology teaching and have obtained the good result by intergroting teaching conteut and teaching resoures,selecting high-level teaching team,case teaching,PBL teaching and multi-media teaching.
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Objective To evaluate the value of combined use of laparoscopy and hysteroscopy in the diagnosis of infertility. Methods Clinical data of 168 cases of infertility receiving examinations with laparoscopy and hysteroscopy from June 1999 to October 2003 were retrospectively reviewed.Results Hysteroscopic examinations found intrauterine diseases in 79 cases(79/168,47.0%),including 46 cases of endometrial hyperplasia or polyps(46/79,58.2%).Laparoscopic examinations showed organic pelvic diseases in 99 cases,including 85 cases of chronic pelvic inflammation,endometriosis or polycystic ovarian syndrome(85/99,85.9%).Both laparoscopy and hysteroscopy gave normal findings in 15 cases and abnormal findings in 39 cases.Unilateral or bilateral tubal obstruction was found in 90 cases by tubal patency tests under hysteroscope(90/168,53.6%) and in 78 cases by laparoscopy(78/168,46.4%). Conclusions Combined use of laparoscopy and hysteroscopy offers accurate diagnostic evidences in examinations of infertility.
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<p><b>OBJECTIVE</b>To observe the effects of Dexamethasone (Dex), a synthetic glucocorticoid, on glucocorticoid receptor expression in the human ovarian carcinoma cell line 3AO. The molecular mechanism of glucocorticoid (GC) on 3AO cells was also studied.</p><p><b>METHODS</b>The expression and regulation of the glucocorticoid receptor in 3AO cells was studied by utilizing radioligand binding assay and quantitative RT-PCR.</p><p><b>RESULTS</b>High affinity and low capacity GR existed in 3AO cells, in addition, GR binding activity was down-regulated by Dex in a time-dependent manner, to a level about 28.34% of control following 24 hours treatment, with a concomitant decrease in GR mRNA. The induction of alkaline phosphatase (AKP) activity by Dex was reversed by RU486, a potent glucocorticoid antagonist.</p><p><b>CONCLUSION</b>In 3AO cells, functional GR which can be down-regulated by Dex at the protein and mRNA level, exists suggesting that the regulating effects of Dex on GR occur at least partially at the GR mRNA level, and that the cellular effects of Dex on 3AO cells might be mediated by GR.</p>
Subject(s)
Female , Humans , Dexamethasone , Pharmacology , Dose-Response Relationship, Drug , Mifepristone , Pharmacology , Ovarian Neoplasms , Chemistry , Drug Therapy , RNA, Messenger , Receptors, Glucocorticoid , Genetics , Tumor Cells, CulturedABSTRACT
Objective The purpose of this study was to explore the teaching method PBL in gynecology and obstetric education. Methods We took PBL in teaching Acute Gynecological Abdomen Pain in 102 students between 2008 and 2009. Results Questionnaire results and high scores in tests suggested that the students showed great subjective initiative in studies.PBL can cultivate students'self-learning capability,improve their ability of analyzing and solving prob-lems. Conclusion PBL is a better way in clinical medical education and worthwhile to be further researched and carried out.
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Objective: To study the diagnosis， treatm ent and outcome of infants in patients with hyperthyroidism in pregnancy. Methods: The levels of T3，T4，TSH，FT3，FT4 in 40 cases of hyperthyroid gravida and control group were measured before delivery, the r oute of delivery and the outcome of infants were studied, and the neonatal thyroid f unctions were evaluated by the levels of T3，T4，TSH in cord serum samples . Results: The levels of T3，T4，FT3，FT4 in non-treatm ent group were higher than that of treatment group and control(P<0.01); an i ncreased rate of forceps and cesarean in hyperthyroid gravida was seen compared with that in control group, about 90%(36/40); the body weights of infants in no n-treatment group were lower than that in treatment and control group. There wa s a case of neonatal hyperthyroidism in non-treatment group. Conclusion : Hyperthyroidism should be diagnosed and treated earlier and there is little side effects on the outcome of infants.
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Objective:To study the effects of dexamethasone (Dex), a synthetic glucocorticoid, on the proliferation and cell cycle of human breast carcinoma cell line MCF-7. Methods: MCF-7 cells were treated with different concentrations of Dex (10~(-10)-10~(-6) mol/L). Cell proliferation was evaluated by viable cell count and alkaline phosphatase( AKP) activity was also determined. The cell cycle was examined with flow cytometry and p21/WAF1 expression was detected with Western blot analysis. Results: Dex inhibited the proliferation of MCF-7 cells, with the cell number being 70% of the control group 5 d after treatment with Dex(10~(-7) mol/L). Dex also induced G_0/G_1 arrest of MCF-7 cells phase. AKP activity increased significantly after treatment with Dex in a time- and dose-dependent manner. Dex had no obvious effect on p21/WAF1 expression. (Conclusion:) Glucocortocoids can obviously inhibit the proliferation of MCF-7 cells and induce G_0/G_1 phase arrest.
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In order to investigate the possibility that oxytocin (OT) is involved in stress reaction, the effect of OT or antioxytocin serum (AOTS) on rat swimming maintaining time was observed. On intraventrncularly administrating 0.625, 1.25, 2.5 and 5.0ng OT 5min before swimming,the swimming maintaining time was 29.32?5.84%, 44.92?4.54%. 60.18?4.21% and 80.48?3.62% shorter than that before injection,respectively.All the swimming maintaining time of the experimental groups was shorter significantly than that of the control group which was intraventricularly injected saline (p