ABSTRACT
Anti- inflmmatory effects of ferulofen(FL)and its mechanisms were studied. In the rat carrageenin pleurisy, FL produced a dose-related reduction of exudate volume, protein contents and leucocyte numbers in the exudate. FL also reduced activity of ?-glucuronidase in the exudate only in higher dose 3 h after carrageenin. These results suggest that FL has a marked anti-inflammatory action and its mechanisms may be similar to indomethacin. Ia vitro, FL caused a dose-dependent inhibition of hydrogen peroxide release from rat peritioneal macrophages ( M0 ) stimulated by opsonized zymosan. It suggested that its anti-inflammatory mechanisms may also relate to inhibitting cell activation. ?-receptor agonist ( Isoproterenol, ISO), in a ineffective dose, synergized with FL in inhibitting M H2O2 release and the synergic mechanism remains to be established.
ABSTRACT
This paper reports that the protective effects of SOD on the experimental gastric ulcers in the mice and erythrocyte membranes, as well as the 125I-SOD traced examination to be studied. The radioactive 125I labelling SOD is using by Iodogen solid phase method. The results of traced examination demonstrated that 125I-SOD could be absorbed into the blood rapidly,and distributed to various organs. The renal radioactivity is highest. The radioactivity in erythrocytes (peak phase) has been accounting for 18. 2% in the whole blood. The radioactivity of bound form in the plasma is only accounted for 12. 5%. It shows that the 125I-SOD was mostly degradation and deiodination. The action of theexogenous O2 free radicals on the erythrocytes showed that the SOD have been markedly inhibited the peroxide damage of O2on the erythrocyte membranes, which inhibitory effect was increased with the concentration of the SOD raised. The effect of SOD on the IM-HCI induced the gastric ulcers, an inhibitory and protective action occur too. In the group of SOD treatment, the gastric mucosal membranes lipid peroxidation was inhibited and the pathological changes remited.
ABSTRACT
Effects of different concentrations of Zinc-glycine chelates and their combination with ( SAC ) on DNA synthesis in human peripheral lymphocytes were observed. These results indicated that incorporation of 〔3H〕 -TdR in DNA of lymphocytes were risen (SI and cpm ) with a concentrations of 4.5 and 9?10-5mol/L Zinc -glycine ( P