ABSTRACT
OBJECTIVE@#To measure the upper airway of obstructive sleep apnea-hypopnea syndrome by speed CT. We can predict the airway obstruction plane with the airway plane data and compliance in OSAHS patients. Through this measurement, we can provide assistance for clinical diagnosis and treatment.@*METHOD@#This study randomly selected 82 patients diagnosed with OSAHS and 45 cases non-snoring healthy people as control group by the PHILIPS 256-slice CT. The zone volume, sagittal diameter, coronary diameter and cross-sectional area of the narrowest plane in nasopharyngeal area, velopharyngeal area, glossopharyngeal area, hypopharynx area in two groups of quiet respiration and Müller's status were measured.@*RESULT@#In the OSAHS group underwent quiet breathing and Müller movement during CT scanning, the two states about nasopharyngeal coronary diameter, the hypopharynx sagittal diameter and cross-sectional area showed no significant difference, while other groups showed differences between the parameters (P<0.05). There was significant difference (P<0.01) in the velopharyngeal volume, tongue sagittal diameter and volume. Under Müller movement in the OSAHS group and the control group, the hypopharynx volume showed no significant difference. The nasopharyngeal coronary diameter and volume, velopharyngeal cross-sectional area and tongue sagittal diameter were different (P<0.05). The remaining set of parameters showed significant differences (P<0.01). Compared the airway compliance (Müller phase) of the OSAHS group and the control group,the parameters of each group were different (P<0.05), of which the nasopharyngeal sagittal diameter, velopharyngeal volume showed significant difference (P<0.01). Meanwhile, in the same plane, coronary diameter was greater than sagittal diameter (P<0.05) in both the OSAHS group and the control group. The pharyngeal volume measurement was basically consistent to the fiber endoscopy.@*CONCLUSION@#The obstruction plate of OSAHS patients is mostly in the velopharyngeal area and glossopharyngeal area measured with a high speed CT. The volume measurement of upper airway with speed CT can predict airway obstruction plate in patients with OSAHS.
Subject(s)
Humans , Case-Control Studies , Hypopharynx , Nasopharynx , Diagnostic Imaging , Pharynx , Diagnostic Imaging , Sleep Apnea, Obstructive , Diagnostic Imaging , Tomography, X-Ray Computed , Tongue , Diagnostic ImagingABSTRACT
OBJECTIVE@#To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9 (MMP-9) in laryngeal carcinoma and their correlations with clinical features.@*METHOD@#The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma, 28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.@*RESULT@#The expressions of ET-1, MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues (P < 0.05). The expression of ET-1, MMP-9 was associated with clinical stage, T stage and lymph node metastasis. Expression levels of ET-land MMP-9 correlated significantly with each other (r(s) = 0.693, P < 0.05).@*CONCLUSION@#The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoma, Squamous Cell , Metabolism , Pathology , Endothelin-1 , Metabolism , Laryngeal Neoplasms , Metabolism , Pathology , Matrix Metalloproteinase 9 , Metabolism , Neoplasm StagingABSTRACT
OBJECTIVE@#To analyze the expression of transforming growth factor-beta1 (TGF-beta1) in human vocal fold polyps, and explore the pathogenesis of vocal fold polyp.@*METHOD@#The expression of TGF-beta1 were detected in 37 examples of vocal fold polyps and 11 healthy vocal folds by immunohistochemical staining (SP method). Meanwhile, the positive results were compared.@*RESULT@#The percent of positive expression of TGF-beta1 was 56.76% and the number of positive cells was 22.55 +/- 27.31 in vocal fold polyps, both of which were significantly increased compared with the percent of positive expression of TGF-beta1 (18.18%) and the number of positive cells (2.53 +/- 3.75) in healthy vocal folds (P0.05).@*CONCLUSION@#TGF-beta1 may participate in some pathologic changes in vocal cord polyps, such as extracellular matrix accumulation, local fibrosis and formation and development of vocal cord polyps. Manipulating the TGF-beta1 expression in vocal cord polyps may supply a new treatment method.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Case-Control Studies , Laryngeal Diseases , Metabolism , Pathology , Polyps , Metabolism , Pathology , Transforming Growth Factor beta1 , Metabolism , Vocal Cords , Metabolism , PathologyABSTRACT
OBJECTIVE@#To investigate the serum resistin level in healthy volunteers and patients with obstructive sleep apnea syndrome (OSAHS), and study the relationship between OSAHS and obesity, serum resistin level.@*METHOD@#All body's height, weight and calculate body mass index (BMI) were precisely measured. According to the BMI, 35 OSAHS patient were divided into two groups: One group was normal weight patients (BMI:18.5-24.9, 14 cases)and the other group was overweight patients(BMI > or =25, 21 cases). There were 40 healthy volunteers in control group. The blood pressure, fasting levels of plasma glucose (FPG), total cholesterol (TC) and triglyceride (TG), and test resistin level in plasma were detected. The apnea-hypopnea index (AHI), the average oxygen saturation and the minimum oxygen saturation in 35 OSAHS patients were examined with Polysomnography.@*RESULT@#(1) Compared with healthy volunteers, serum resistin level, BMI, TG, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in OSAHS patients were all enhanced (P < 0.05); (2) In OSAHS patients, the indexes of BMI, SBP, DBP and AHI for overweight group were notably higher than those for normal weight group (P < 0.05). (3) In OSAHS patients, BMI was positively correlated with AHI and SBP, and negatively correlated with the average oxygen saturation and the minimum oxygen saturation. (4) Serum resistin level was positively correlated with TG, FPG and DBP. Multiple stepwise regression analysis revealed that serum resistin level was associated with TG and FPG.@*CONCLUSION@#In OSAHS patients, serum resistin level is enhanced and accompany with the disorder of blood pressure and serum lipid. Obesity or abdomen obesity may aggravate the hypoxia in OSAHS patients. Serum resistin level is positively correlated with TG, FPG and DBP. TG and FPG are important factors in serum resistin level, which indicate that the resistin is highly associated with lipid metabolism and glycometabolism, and possibly connect with diastolic blood pressure (DBP).