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Objective:To investigate the relationships between the expression of insulin-like growth factor-1 (IGF-1) in the gastric cancer tissue and the clinicopathological parameters in the gastric cancer patients in China with Meta-analysis, and to provide the evidence-based medical evidence for the diagnosis and treatment of gastric cancer.Methods:The literatures about the relationships between the positive expression rate of IGF-1and the clinicopathological paramters in the gastric cancer patients were searched comprehensively in PubMed, China National Knowledge Infrastructure, Weipu Chinese Science and Technology Journal Database, Wanfang Database and China Biomedical Literature Database.Review Manager 5.2software was used to conduct Meta analysis on the literatures that met the inclusion criteria.Results:There were 11articles in the literatures were selected, including993cases in gastric cancer group and 601cases in non-tumor gastric mucosal tissue control group.Meta-analysis showed the significant differences in the positive expression rates of IGF-1between gastric cancer group and control group (OR=9.05, 95％CI:6.82-12.01) , poorly differentiated gastric cancer group and moderately-highly differentiated group (OR=1.53, 95％CI:1.14-2.06) , involving full-thickness group and unaffected fullthickness group (OR=0.16, 95％CI:0.09-0.28) , lymph node metastasis group and non-lymph node metastasis group (OR=0.12, 95％CI:0.08-0.17) , TNM stageⅢ-Ⅳgroup and TNM stageⅠ-Ⅱgroup (OR=0.21, 95％CI:0.13-0.33) .Conclusion:The high expression of IGF-1in gastric cancer tissue is closely related to the occurrence, development, invasion and metastasis of tumor in the gastric cancer patients in China.The abnormal expression of IGF-1could be used as a risk factor for carcinogenesis of gastric mucosal cells and a valuable molecular biological marker for early diagnosis and treatment of gastric cancer.
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Objective: To investigate the relationships between the expression of insulin-like growth factor-1 (IGF-1) in the gastric cancer tissue and the clinicopathological parameters in the gastric cancer patients in China with Meta-analysis,and to provide the evidence-based medical evidence for the diagnosis and treatment of gastric cancer. Methods: The literatures about the relationships between the positive expression rate of IGF-1 and the clinicopathological paramters in the gastric cancer patients were searched comprehensively in PubMed, China National Knowledge Infrastructure, Weipu Chinese Science and Technology Journal Database,Wanfang Database and China Biomedical Literature Database. Review Manager 5. 2 software was used to conduct Meta analysis on the literatures that met the inclusion criteria. Results: There were 11 articles in the literatures were selected∗ including 993 cases in gastric cancer group and 601 cases in non-tumor gastric mucosal tissue control group. Meta-analysis showed the significant differences in the positive expression rates of IGF-1 between gastric cancer group and control group (OR = 9. 05,95% CI: 6.82 12.01), poorly differentiated gastric cancer group and moderately-highly differentiated group (OR=l. 53 95% CI: 1.14-2.06). involving full-thickness group and unaffected full- Thickness group (OR = 0. 16. 95% CI: 0. 09 - 0. 28). lymph node metastasis group and non-lymph node metastasis group (GR = 0. 12, 95% CI: 0.08 0.17), TNM stage 111 - IV group and TNM stage 1-1! group (OR = 0.21, 95% CI: 0. 13 0. 33). Conclusion: The high expression of IGF-1 in gastric cancer tissue is closely related to the occurrence, development, invasion and metastasis of tumor in the gastric cancer patients in China. The abnormal expression of IGF-1 could be used as a risk factor for carcinogenesis of gastric mucosal cells and a valuable molecular biological marker for early diagnosis and treatment of gastric cancer.
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The prevalence of food allergy has increased in recent decades and the clinical focus on allergy has shifted from treatment to prevention. There have been dramatic changes of infant feeding guidelines on allergy preven-tion,especially the breastfeeding and the import of solid foods. In order to help clinician update their feeding know-ledge,the literatures related to infant feeding and food allergy have been retrieved and reviewed,and the prevention of food allergy has discussed.
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Objective To study changes and meaning of serum IL -4,IL -10,IFN -gamma,TGF -beta 1 level in patients with delayed encephalopathy after carbon monoxide poisoning.Methods From January 2011 and June 2014 in our hospital,40 cases of DEACMP patients were selected as group A;the 40 patients with DEACMP was divided into 12 cases of mild cognitive dysfunction,mild cognitive dysfunction in 20 cases,8 cases of severe cognitive dysfunction.40 cases with acute carbon monoxide poisoning (ACMP)patients were selected as group B;40 cases of healthy subjects were selected as healthy controls.Serum interleukin 4 and interleukin 10(IL -4)(IL -10),interfer-on gamma (IFN -gamma),conversion,growth factor beta 1 (TGF -beta 1)content were tested.Results In Group A and group B serum IL -4 levels were lower than that of healthy controls (P <0.01),and serum levels of IL -10 in group B were higher than that in group A and healthy controls (P <0.01),serum level of IFN -gamma in group A and group B was higher than the healthy controls (P <0.01),and in group A IFN -gamma levels were higher than group B (P <0.01),while in group A serum TGF -beta 1 level was lower than B group and the control group (P <0.01),and in group B TGF -beta 1 level was higher than the control group (P <0.01);With cognitive impairment aggravating of DEACMP patients,IL -4,IL -10,TGF -beta 1 levels were on the decline,and IFN -gamma level was increasing (P <0.01).Conclusion DEACMP patients serum and cerebrospinal fluid of IL -4,IL -10,IFN -gam-ma,TGF -beta measures such as abnormal expression,showed that the onset of DEACMP may be related to neural immune injury.Serum IL -4,IL -10,IFN -gamma and TGF -beta of DEACMP patients exists abnormal expression Serum IL -4,IL -10,IFN -gamma and TGF -beta levels are also related to the degree of cognitive impairment of DEACMP patients.The onset and progress of DEACMP may be associated with neural immune injury.
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Objective To examine the effects of weight loss on functional state of female judokas. Methods Twelve female judokas belonging to Shanghai female judo team were tested at different periods(first,second,third phases and last phase) during weight loss a month before competition. The changes of physiological and biochemical indexes in different periods were observed and all the data was statistically analyzed. Results Previous three phases,the Fat% in weight loss group was decreased compared with basic data (P