ABSTRACT
Objective To investigate the expression of TGF-?1 and Smad 3, 7 in rats renal tissue after unilateral ureteral obstruction(UUO) and the effect of Shentong capsule on their expressions. Methods Sixteen rats underwent UUO and were devided into operation group and Shentong treatment group, additional 8 rats were shame operation group. The pathological change of renal tissues were examined by light microscopy 8 days after operation. The extent of renal fibrosis was determined by measuring the area of renal interstitial fibrosis. Immunhistochemistry was applied to detect the expression of TGF-?1 and Smad 3,7. Results In comparison with shame operation group, the expression of TGF-?1 and Smad 3 in operation group significantly increased, and the expression of Smad 7 significantly decreased(P