ABSTRACT
Radiation-induced brain injury (RBI) is the most serious complication of head and neck tumor after radiotherapy. The pathogenesis of RBI is complicated, and the clinical course is irreversible, while no effective treatment available. The activation of glial cells is one of the main theories of RBI, and the prevention and treatment of RBI by targeting glial cells is the focus of current research. As a post-transcriptional regulatory factor, microRNA (miRNA) has been confirmed to be involved in regulatingglial cell radiosensitivity, inflammation type transformation, autophagy, exosomatic, long non-coding RNA (lncRNA), circular RNA (circRNA) and other related pathways, thereby mediating the occurrence and development of cascade reaction of inflammatory injury and neurological function repair of central nervous system (CNS) disease. Therefore, the establishment of miRNA - glial regulatory network may provide a new strategy for the prevention and treatment of RBI.
ABSTRACT
PURPOSE: Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma. MATERIALS AND METHODS: Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA. RESULTS: Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative. CONCLUSION: Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
Subject(s)
Adolescent , Female , Humans , Adenocarcinoma, Papillary , Asian People , Epithelial Cells , Glial Fibrillary Acidic Protein , Herpesvirus 4, Human , Immunohistochemistry , In Situ Hybridization , Keratins , Mucin-1 , Nasopharynx , RNA , Thyroglobulin , Thyroid Gland , Transcription Factors , VimentinABSTRACT
Objective To explore the effect of earplugs on the reduction of noises in the wards with a few patients after gynecological surgery.Methods Two hundred and fifty-four patients hospitalized in our hospital after gynecological surgery from March 2012 to May 2013 were divided into control group(n=124)and observation group(n=130). The observation group was managed with earplugs and the control group patients received routine nursing. The two groups were compared in terms of breathing,heart rate,blood pressure,24 h scores on anxiety before and after operation.Results The postoperative respiration,heart rate,blood pressure of the observation group patients was significantly lower than those of control group(all P<0.05),anxiety score was significantly lower than that of the control group(P<0.01). Conclusions Earplugs can create a quiet environment in wards with a few patients after gynecological surgery and help to stabilize vital signs and reduce anxiety.
ABSTRACT
AIM:To observe the effect of motilium on bronchial asthma associated with gastroesophageal reflux(GER BA). METHODS:50 cases of GER BA, were treated with routine anti asthma and motilium 20 mg tid,ranitidine 0.3 g,amoxicillin 0.5 g and metronidazolum 0.2 g tid for chronic gastritis cases, and losec 20 mg for the gastric acid rdflux at night. The treatment lasted for 1-4 wk, and then stopped to observe the response of the treatmeat. The recurrent cases would be treated as the above again. RESULTS:45 cases were cured in the 4 wk,no case recrudesced in 6 mon. 5 cases needed another the treatment for 1-4 wk since the recurrence, and 4 of the 5 cases were cured. CONCLUSION: Motilium has a good curative effect in preventing and curing bronchial asthma associated with gastroesophageal reflux.entfor1 -4wksin
ABSTRACT
AIM: To analyze the relation of hypoglycemic coma and xiaoke pills. METHODS: The relation of hypoglycemic coma and xiaoke pills were analyzed retrospectively from the five cases of old patients. RESULTS: All the five old patients with diabetes died of hypoglycemic coma on the seventh day to the thirteenth day, after taking xiaoke pills. CONCLUSION: It must be cautious for xiaoke pills to treat diabetes in elderly patients.