ABSTRACT
AIM: To investigate the pharmacodynamic effects of Huahong Capsule on the anti-bacteria,anti-inflammation,antipyretic and analgesic effects. METHODS: The death rate of mice infected by staphylococcus aureus or Escherichia coli was observed to investigate the antibacterial effects.Crotonoil-induced auricle edema,cotton ball-induced granuloma and trauma-induced toe congestion were performed to investigate the anti-inflammatory effects in mice.Endotoxin-induced fever was performed to observe the antipyretic effect in rabbit.Mouse twisting numbers induced by acetic acid,mouse pain threshold after heat stimulation and rat twisting numbers of dysmenorrhea were observed to investigate the analgesic effects. RESULTS: Huahong Capsule had a tendency to decrease the death rate of mice infected by bacteria.It could remarkably inhibit edema of auricle of ear,formation of granuloma and toe congestion in mice.It decreased obviously the temperature raised by endotoxin in rabbit.It could reduce mouse twisting numbers and prolong pain thresholds. CONCLUSION: Huahong Capsule has pharmacological effects in accordance with its clinical functions and uses.