ABSTRACT
Splenic involvement and multiple abscess formation in tuberculosis disease [TB] are rare. The fact that the most common cause of splenic abscess formation is infection, this complication should always be in the differential diagnosis, especially in patients with febrile diseases and immune deficiency and or intravenous drug abuser. Tuberculosis splenic abscess may be the first and only sign of tuberculosis. A 30- year old addicted and HIV positive man admitted to Bu-Ali hospital of Tehran with symptoms of fever, chills, fatigue, weight loss since 2 months ago, characteristic sepsis, jaundice and very bad general condition. Ultra-sonography and CT scan showed some masses [abscess] in the liver, spleen, pancreas and some Para-aortic lymph nodes. Patient underwent laparotomy because of abdominal pain, tenderness and rebound tenderness. Abundant small abscesses were seen in the spleen during operation and then splenectomy was done. The patient passed away next day after operation. Pathologic study revealed multiple abscesses in the spleen containing numerous positive acid-fast bacilli. In patients with fever and other symptoms of infectious diseases, especially persisting symptoms, underlying conditions, immune deficiency and malignancy should be considered. Advent of AIDS has again increased the frequency of tuberculosis. Therefore, Clinicians should bear in mind tubeculosis in those who are addicted and HIV positive. TB may be presented by abdominal abscesses in abdominal viscera in immunocompromised patients
ABSTRACT
Chronic gastritis is defined as the presence of chronic mucosal inflammatory changes leading eventually to mucosal atrophy and epithelial metaplasia. It is notable for distinct causal subgroups and for patterns of histological alterations that vary in different parts of the world. By far the most important aetiological association is chronic infection by the bacillus Helicobacter pylori (Hp). The organism is a worldwide pathogen that has the highest infection rates in developing countries including Iran. In this study, samples confirmed for the diagnosis of chronic gastritis from 100 Hp-positive and 36 Hp-negative patients, were reevaluated histopathologically to determine the severity of inflammation, the presence of active gastritis, lymphoid follicle(s), glandular atrophy and intestinal metaplasia. Seventy-five percent of the samples showed mild inflammation, whilst moderate and severe inflammation was seen respectively in 24% and about 1% of the cases. Among the evaluated variables, only activity and intestinal metaplasia had statistically significant associations with Hp (p < 0.05) in this survey.