ABSTRACT
Objective To evaluate the effectiveness of autologous platelet-rich gel (APG)in the repair of diabetic foot ulcers.Methods This study was a single-center,prospective,randomized controlled trial.A total of 60 patients with diabetic foot ulcers (Wagner grade 2 - 3 )were randomly divided into autologous APG group (treatment group)and recombinant bovine basic fibroblast growth factor gel group (control group).After 8 weeks, we compared wound healing rate and wound healing time at five levels (overall ulcer,superficial ulcer,sinus ulcer, Wagner 2 and Wagner 3)in the two groups.Results In APG treatment group and control group,the healing rate of overall sample ulcer (93.33% vs .63.33%,P =0.005),sinus ulcer (84.62% vs .36.36%,P =0.033),Wagner 3 (81.82% vs .30%,P =0.030)differed significantly,but did not significantly differ in superficial ulcer (100%vs .78.95%,P =0.106)or Wagner 2 (100% vs .80%,P =0.106).Ulcer healing time was 31 d vs .41.5 d,23 d vs .32 d,32 d vs .56 d,25 d vs .32 d,38 d vs .56 d,with significant difference between the two groups (P <0.05). Conclusion Autologous platelet-rich gel can effectively increase the curative rate of diabetic foot and shorten healing time.
ABSTRACT
ObjectiveTo study the curative effect of Zhisousan in treatment of children with cough variance asthma. Methods 110 cough variance asthma children were randomly divided into treatment group and control group,each group 55 patients.The control group received western medicine's ordinary treatment,and the treatment group were given Zhisousan except received western medicine.Then the therapeutic effect were compared between the two groups after two weeks treatment. ResultsThe treatment group's total effective rate 90.9% was obviously higher than the control group 76.4%,and there was significant statistical difference(x2 = 4.25,P＜0.05);The trentment group's cough recurrence rate was 16.3%,and the control group was 60.0%,and there was significant statistical difference(x2 = 22.18,P＜0.01). ConclusionThe therapeutical method of Zhisousan combined with western medicine could obviously raise the therapeutic effect.
ABSTRACT
Both diabetes mellitus and cognitive impairment are frequent disorders in elderly people,Diabetes mellitus as a risk factor for stroke can cause vascular dementia.However,it is still no final conclusion whether it can cause Alzheimer' s disease or not,Most researches indicate that two diseases are positive correlation,but a few suggest no correlation between them.The brain of Alzheimer's disease has obvious phenomenon of insulin resistance,insulin and insulin sensitizers drugs can not only improve the sensitivity of insulin receptors,but also reduce the inflammatory response,promoting A?-amyloid release and clearance,benefiting of improvement in memory function.