ABSTRACT
Objective: To compare the efficacy of ondansetron with a combination of ondansetron and dexamethasone after elective laparoscopic cholecystectomy in terms of postoperative nausea and vomiting
Study Design: Randomized controlled trial
Place and Duration of Study: Department of Surgery, Combined Military Hospital Rawalpindi Pakistan, from Apr 2014 to Mar 2015
Materials and Methods: Two hundred and twenty two patients fulfilling the inclusion criteria were selected for study and divided into two groups of 111 each. Group A was given ondansetron while group B was given combination of ondansetron and dexamethasone at induction of general anesthesia. Patients of both groups were observed at 24 hours postoperatively for nausea and vomiting
Results: Sixty six patients in group A had nausea as compared to 50 patients in group B [p-value 0.03], 46 patients in group A had vomiting as compared to 19 patients in group B [p-value <0.001], showing statistically significant difference between the two groups
Conclusion: Postoperative nausea and vomiting is significantly lower in ondansetron and dexamethasone combination group as compared to ondansetron alone group after elective laparoscopic cholecystectomy
ABSTRACT
Objective: To compare the mean post-operative analgesic requirement in non-closure and closure of peritoneum during open appendectomy
Study Design: Randomized controlled trial
Place and Duration of Study: Department of General Surgery Combined Military Hospital Quetta, from 1[st] August 2014 to 30[th] April 2015
Material and Methods: A total of 60 patients were included in this study and were divided into two groups of 30 each. Patients in group A underwent open appendectomy with closure of peritoneum while patients in group B had non-closure of peritoneum during the same procedure. Post-operatively, pain severity was assessed on visual analogue scale [VAS] numeric pain distress scale. On presence of VAS numeric pain distress scale between 5 to 7, intramuscular [IM] diclofenac sodium was given and on score >7, intravascular [IV] tramadol was given. The final outcome was measured at day 0 and day 1
Results: Pain score and analgesic requirements were significantly less in non-closure group than closure group on day 0 and day 1, showing statistically significant difference between the two groups
Conclusion: Mean post-operative analgesic requirement is significantly less in non-closure group as compared to closure group during open appendectomy