ABSTRACT
Dysembryoplastic neuroepithelial tumour (DNT) of the central nervous system is a recently recognized entity. We describe the clinical and characteristic histomorphological features in a patient with DNT. As this lesion carries a favourable prognosis, it becomes essential to make an accurate histopathological diagnosis.
Subject(s)
Central Nervous System Diseases/diagnosis , Central Nervous System Neoplasms/diagnosis , Child, Preschool , Diagnosis, Differential , Hamartoma/diagnosis , Humans , Male , Neuroectodermal Tumors, Primitive, Peripheral/diagnosisABSTRACT
Granular cell tumours of the neurohypophysis are uncommon and only 30 cases are documented in the literature till 1994. In this communication, the salient clinical and histomorphological features in two patients with granular-cell tumour of the neurohypophysis are described.
Subject(s)
Choristoma/diagnosis , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Pituitary Diseases/diagnosis , Pituitary Gland, PosteriorABSTRACT
Gliomatosis cerebri is a vary rare neoplastic lesion of the central nervous system. An intra-vitam diagnosis of gliomatosis cerebri can be suggested with a steleolactic biopsy of the lesion in conjunction with Magnetic Resonance Imaging (MRI) findings in the brain.
Subject(s)
Adult , Biopsy , Brain Neoplasms/diagnosis , Frontal Lobe/pathology , Glioma/diagnosis , Humans , Magnetic Resonance Imaging , MaleABSTRACT
Gangliogliomas are one of the uncommon tumours of central nervous system. Since these tumours have been associated with an indolent clinical course and benign biological behaviour, it is essential to make an accurate histopathological diagnosis of ganglioglioma. In this study the salient clinical and histopathological features in six patients with intracranial ganglioglioma are described.
Subject(s)
Adolescent , Adult , Brain Neoplasms/diagnosis , Child , Female , Ganglioglioma/diagnosis , Humans , Magnetic Resonance Imaging , Male , Retrospective Studies , Tomography, X-Ray ComputedABSTRACT
In this study, thirty-two non-functional and eighteen functional pituitary adenomas were analysed for the presence of argyrophilic nucleolar organizer regions (Ag-NORs) in paraffin sections, using an one-step silver-colloidal staining method. Differences in the mean Ag-NOR numbers of functional pituitary adenomas were statistically significant than those of non-functional pituitary adenomas. It is being emphasised that evaluation of Ag-NOR count is a more reliable index than the presence of mitotic figures in predicting the proliferative activity as well as possibility of recurrence in a patient with pituitary adenoma.
Subject(s)
Adenoma/pathology , Adult , Aged , Female , Humans , Male , Middle Aged , Nucleolus Organizer Region/pathology , Pituitary Neoplasms/pathology , Silver , Staining and LabelingABSTRACT
Central neurocytomas are uncommon intracranial neoplasms. More than one hundred cases are documentated in the literature. In this report we describe the clinical and histopathological features in two patients with intraventricular neurocytoma. As the light microscopic features of neurocytoma resemble with that of an oligodendroglioma, it is essential to differentiate these two tumours, using either ultrastructural or immunohistochemical techniques.
Subject(s)
Adult , Cerebral Ventricle Neoplasms/pathology , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Male , Neurocytoma/pathology , Oligodendroglioma/pathologyABSTRACT
Histopathological examination of surgical specimens in two patients with an operative diagnosis of meningioma, revealed the presence of dense nodular aggregation of lymphocytes, plasma cells and conspicious absence of meningothelial components. Possibilities of lymphoreticular malignancy, myeloproliferative disorders and other causes for various inflammatory diseases were excluded by appropriate investigation in these two patients. Pathogenesis of this localised lymphocyte-plasma cell aggreation in the dura manifesting as a space-occupying lesion could not be defined in these two patients. It is emphasised that this benign lesion should be recognised as well as distinguished from secondary lymphomatous deposits and solitary plasmacytoma of the dura.
Subject(s)
Adult , Diagnosis, Differential , Humans , Male , Meningioma/diagnosis , Meningitis/diagnosis , Plasmacytoma/diagnosisABSTRACT
Primary cranial Ewing's sarcoma is an exceptionally rare lesion and only eleven cases have so far been reported. In this report we describe a case of primary Ewing's sarcoma arising from the floor of middle cranial fossa. Salient clinical, neuroradiological and light microscopic features in this case are described. A brief review of earlier published cases of primary cranial Ewing's sarcoma are also presented.
Subject(s)
Child , Humans , Male , Sarcoma, Ewing/pathology , Skull Neoplasms/pathologyABSTRACT
In this study, clinical and histopathological features of primary lymphomas of the brain have been described in eight patients. The primary nature of lymphoma in these patients was confirmed by extensive clinical as well as radiological investigations and supported by a detailed histopathological examination. Computerised tomography (CT) scan showed multiple intra-cerebral lesion in two patients and in six patients the lesion was solitary. Although primary lymphoma of the brain carries poor prognosis, it is essential that these tumours should be accurately diagnosed as well as should be distinguished from secondary tumours.